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STRINGSTRING
FRY FRY ZSCAN30 ZSCAN30 FGL1 FGL1 FASTKD1 FASTKD1 ZNF154 ZNF154 CDKL2 CDKL2 STEAP4 STEAP4 TMEM138 TMEM138 NPHP1 NPHP1 PPP1R14B PPP1R14B EGF EGF
"CDKL2" - Cyclin-dependent kinase-like 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CDKL2Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily (493 aa)    
Predicted Functional Partners:
STEAP4
Metalloreductase STEAP4; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin- resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation; STEAP family (459 aa)
      
   
  0.633
TMEM138
Transmembrane protein 138; Required for ciliogenesis (162 aa)
      
   
  0.584
FGL1
Fibrinogen-like protein 1; Has hepatocyte mitogenic activity; Fibrinogen C domain containing (312 aa)
            
  0.548
ZNF154
Zinc finger protein 154; May be involved in transcriptional regulation; Zinc fingers C2H2-type (437 aa)
            
  0.536
ZSCAN30
Zinc finger and SCAN domain-containing protein 30; May be involved in transcriptional regulation; SCAN domain containing (494 aa)
            
  0.470
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (1207 aa)
            
  0.468
PPP1R14B
Protein phosphatase 1 regulatory subunit 14B; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity) (147 aa)
            
  0.454
NPHP1
Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photorec [...] (733 aa)
      
   
  0.453
FASTKD1
FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family (847 aa)
            
  0.452
FRY
Protein furry homolog; Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation; Belongs to the furry protein family (3013 aa)
        
      0.439
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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