node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDKL2 | EGF | ENSP00000412365 | ENSP00000265171 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro | 0.468 |
CDKL2 | FASTKD1 | ENSP00000412365 | ENSP00000400513 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | 0.452 |
CDKL2 | FGL1 | ENSP00000412365 | ENSP00000381133 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Fibrinogen-like protein 1; Has hepatocyte mitogenic activity; Fibrinogen C domain containing | 0.548 |
CDKL2 | FRY | ENSP00000412365 | ENSP00000445043 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Protein furry homolog; Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation; Belongs to the furry protein family | 0.439 |
CDKL2 | NPHP1 | ENSP00000412365 | ENSP00000313169 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photorec [...] | 0.453 |
CDKL2 | PPP1R14B | ENSP00000412365 | ENSP00000310117 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Protein phosphatase 1 regulatory subunit 14B; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity) | 0.454 |
CDKL2 | STEAP4 | ENSP00000412365 | ENSP00000369419 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Metalloreductase STEAP4; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin- resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation; STEAP family | 0.633 |
CDKL2 | TMEM138 | ENSP00000412365 | ENSP00000278826 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Transmembrane protein 138; Required for ciliogenesis | 0.584 |
CDKL2 | ZNF154 | ENSP00000412365 | ENSP00000421258 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Zinc finger protein 154; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.536 |
CDKL2 | ZSCAN30 | ENSP00000412365 | ENSP00000392371 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | Zinc finger and SCAN domain-containing protein 30; May be involved in transcriptional regulation; SCAN domain containing | 0.470 |
EGF | CDKL2 | ENSP00000265171 | ENSP00000412365 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.468 |
FASTKD1 | CDKL2 | ENSP00000400513 | ENSP00000412365 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.452 |
FGL1 | CDKL2 | ENSP00000381133 | ENSP00000412365 | Fibrinogen-like protein 1; Has hepatocyte mitogenic activity; Fibrinogen C domain containing | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.548 |
FRY | CDKL2 | ENSP00000445043 | ENSP00000412365 | Protein furry homolog; Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation; Belongs to the furry protein family | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.439 |
NPHP1 | CDKL2 | ENSP00000313169 | ENSP00000412365 | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photorec [...] | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.453 |
NPHP1 | TMEM138 | ENSP00000313169 | ENSP00000278826 | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photorec [...] | Transmembrane protein 138; Required for ciliogenesis | 0.841 |
PPP1R14B | CDKL2 | ENSP00000310117 | ENSP00000412365 | Protein phosphatase 1 regulatory subunit 14B; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity) | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.454 |
STEAP4 | CDKL2 | ENSP00000369419 | ENSP00000412365 | Metalloreductase STEAP4; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin- resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation; STEAP family | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.633 |
STEAP4 | ZNF154 | ENSP00000369419 | ENSP00000421258 | Metalloreductase STEAP4; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin- resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation; STEAP family | Zinc finger protein 154; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.491 |
TMEM138 | CDKL2 | ENSP00000278826 | ENSP00000412365 | Transmembrane protein 138; Required for ciliogenesis | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily | 0.584 |