• Version:
  • 11.0 [archived version]
STRINGSTRING
VEPH1 VEPH1 FNIP2 FNIP2 ANKRD55 ANKRD55 C4orf45 C4orf45 FAM188A FAM188A CACNG8 CACNG8 POTED POTED
"C4orf45" - Uncharacterized protein C4orf45 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
C4orf45Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45 (186 aa)    
Predicted Functional Partners:
FNIP2
Folliculin-interacting protein 2; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine- mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1; DENN/MADD domain containing (1114 aa)
           
  0.716
VEPH1
Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Armadillo-like helical domain containing (833 aa)
           
  0.691
FAM188A
Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins (445 aa)
           
  0.489
CACNG8
Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (425 aa)
           
  0.450
POTED
POTE ankyrin domain family member D; Belongs to the POTE family (584 aa)
           
  0.448
ANKRD55
Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing (614 aa)
           
  0.426
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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