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STRINGSTRING
TBC1D17 TBC1D17 SLC4A1AP SLC4A1AP TBC1D15 TBC1D15 GPN1 GPN1 SUPT7L SUPT7L CCDC121 CCDC121 C2orf16 C2orf16 GTF3C2 GTF3C2 ZNF512 ZNF512 CCDC92 CCDC92 BUD13 BUD13
"CCDC121" - Coiled-coil domain containing 121 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
CCDC121Coiled-coil domain containing 121 (440 aa)    
Predicted Functional Partners:
TBC1D17
TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known (648 aa)
        
      0.855
C2orf16
Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16 (1984 aa)
            
  0.732
ZNF512
Zinc finger protein 512; May be involved in transcriptional regulation; Zinc fingers C2H2-type (567 aa)
            
  0.707
SUPT7L
SPT7 like, STAGA complex gamma subunit (414 aa)
            
  0.694
TBC1D15
TBC1 domain family member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity) (691 aa)
        
      0.665
GPN1
GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA (388 aa)
            
  0.656
GTF3C2
General transcription factor 3C polypeptide 2; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1; General transcription factors (911 aa)
            
  0.633
SLC4A1AP
Kanadaptin; Solute carrier family 4 member 1 adaptor protein (796 aa)
            
  0.588
BUD13
BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family (619 aa)
            
  0.549
CCDC92
Coiled-coil domain containing 92 (331 aa)
      
   
  0.541
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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