node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPR107 | GPR137 | ENSP00000361483 | ENSP00000411827 | Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs to the LU7TM family | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | 0.571 |
GPR107 | TMEM181 | ENSP00000361483 | ENSP00000356057 | Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs to the LU7TM family | Transmembrane protein 181; Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication | 0.540 |
GPR107 | TMEM87B | ENSP00000361483 | ENSP00000283206 | Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs to the LU7TM family | Transmembrane protein 87B; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN); Belongs to the LU7TM family. TMEM87 subfamily | 0.645 |
GPR108 | GPR137 | ENSP00000264080 | ENSP00000411827 | G protein-coupled receptor 108; 7TM orphan receptors | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | 0.662 |
GPR108 | TMEM181 | ENSP00000264080 | ENSP00000356057 | G protein-coupled receptor 108; 7TM orphan receptors | Transmembrane protein 181; Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication | 0.424 |
GPR135 | GPR137 | ENSP00000378548 | ENSP00000411827 | Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | 0.540 |
GPR135 | GPRC5C | ENSP00000378548 | ENSP00000376403 | Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans | G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways; G protein-coupled receptors, Class C orphans | 0.495 |
GPR135 | OR51E2 | ENSP00000378548 | ENSP00000380153 | Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans | Olfactory receptor 51E2; Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure. May also be activated by steroid hormones and regulate cell proliferation. May also function as an olfactory receptor being activated by beta-ionone; Olfactory receptors, family 51 | 0.422 |
GPR135 | OR6V1 | ENSP00000378548 | ENSP00000396085 | Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans | Olfactory receptor 6V1; Odorant receptor; Olfactory receptors, family 6 | 0.570 |
GPR137 | GPR107 | ENSP00000411827 | ENSP00000361483 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs to the LU7TM family | 0.571 |
GPR137 | GPR108 | ENSP00000411827 | ENSP00000264080 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | G protein-coupled receptor 108; 7TM orphan receptors | 0.662 |
GPR137 | GPR135 | ENSP00000411827 | ENSP00000378548 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans | 0.540 |
GPR137 | GPR158 | ENSP00000411827 | ENSP00000365529 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | Probable G-protein coupled receptor 158; Orphan receptor; G protein-coupled receptors, Class C orphans | 0.454 |
GPR137 | GPRC5C | ENSP00000411827 | ENSP00000376403 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways; G protein-coupled receptors, Class C orphans | 0.476 |
GPR137 | OR51E2 | ENSP00000411827 | ENSP00000380153 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | Olfactory receptor 51E2; Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure. May also be activated by steroid hormones and regulate cell proliferation. May also function as an olfactory receptor being activated by beta-ionone; Olfactory receptors, family 51 | 0.505 |
GPR137 | OR6V1 | ENSP00000411827 | ENSP00000396085 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | Olfactory receptor 6V1; Odorant receptor; Olfactory receptors, family 6 | 0.532 |
GPR137 | TM7SF3 | ENSP00000411827 | ENSP00000342322 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | Transmembrane 7 superfamily member 3; Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells. Is a downstream transcriptional target of p53/TP53, and acts as a pro- survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) | 0.464 |
GPR137 | TMEM181 | ENSP00000411827 | ENSP00000356057 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | Transmembrane protein 181; Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication | 0.453 |
GPR137 | TMEM87B | ENSP00000411827 | ENSP00000283206 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | Transmembrane protein 87B; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN); Belongs to the LU7TM family. TMEM87 subfamily | 0.453 |
GPR158 | GPR137 | ENSP00000365529 | ENSP00000411827 | Probable G-protein coupled receptor 158; Orphan receptor; G protein-coupled receptors, Class C orphans | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family | 0.454 |