node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADTRP | DHRS12 | ENSP00000229583 | ENSP00000411565 | Androgen-dependent TFPI-regulating protein; Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | 0.665 |
ADTRP | FAM196B | ENSP00000229583 | ENSP00000366582 | Androgen-dependent TFPI-regulating protein; Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family | 0.429 |
DHRS12 | ADTRP | ENSP00000411565 | ENSP00000229583 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | Androgen-dependent TFPI-regulating protein; Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) | 0.665 |
DHRS12 | FAM196B | ENSP00000411565 | ENSP00000366582 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family | 0.686 |
DHRS12 | GGA1 | ENSP00000411565 | ENSP00000341344 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | ADP-ribosylation factor-binding protein GGA1; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | 0.620 |
DHRS12 | MXI1 | ENSP00000411565 | ENSP00000331152 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins | 0.680 |
DHRS12 | NKX3-1 | ENSP00000411565 | ENSP00000370253 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | Homeobox protein Nkx-3.1; Transcription factor, which binds preferentially the consensus sequence 5’-TAAGT[AG]-3’ and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells; Belongs to the NK-3 homeobox family | 0.611 |
DHRS12 | NUDT17 | ENSP00000411565 | ENSP00000334437 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Nudix hydrolase family | 0.757 |
DHRS12 | STARD13 | ENSP00000411565 | ENSP00000338785 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | StAR-related lipid transfer protein 13; GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells | 0.691 |
DHRS12 | TMCO5A | ENSP00000411565 | ENSP00000327234 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family | 0.791 |
DHRS12 | TMEM225 | ENSP00000411565 | ENSP00000364166 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC | 0.797 |
DHRS12 | TRAFD1 | ENSP00000411565 | ENSP00000257604 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity) | 0.685 |
FAM196B | ADTRP | ENSP00000366582 | ENSP00000229583 | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family | Androgen-dependent TFPI-regulating protein; Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) | 0.429 |
FAM196B | DHRS12 | ENSP00000366582 | ENSP00000411565 | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | 0.686 |
GGA1 | DHRS12 | ENSP00000341344 | ENSP00000411565 | ADP-ribosylation factor-binding protein GGA1; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | 0.620 |
GGA1 | STARD13 | ENSP00000341344 | ENSP00000338785 | ADP-ribosylation factor-binding protein GGA1; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif | StAR-related lipid transfer protein 13; GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells | 0.555 |
MXI1 | DHRS12 | ENSP00000331152 | ENSP00000411565 | Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily | 0.680 |
MXI1 | NKX3-1 | ENSP00000331152 | ENSP00000370253 | Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins | Homeobox protein Nkx-3.1; Transcription factor, which binds preferentially the consensus sequence 5’-TAAGT[AG]-3’ and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells; Belongs to the NK-3 homeobox family | 0.598 |
MXI1 | NUDT17 | ENSP00000331152 | ENSP00000334437 | Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Nudix hydrolase family | 0.658 |
MXI1 | TMCO5A | ENSP00000331152 | ENSP00000327234 | Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins | Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family | 0.684 |