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  • 11.0 [archived version]
STRINGSTRING
LURAP1L LURAP1L MORN1 MORN1 TBCC TBCC TBCD TBCD YTHDF1 YTHDF1 TBCCD1 TBCCD1 KRBA1 KRBA1 GFOD2 GFOD2 PPP2R3B PPP2R3B DNAJB7 DNAJB7 PPP2CB PPP2CB
"TBCCD1" - TBCC domain-containing protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TBCCD1TBCC domain-containing protein 1; Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration (557 aa)    
Predicted Functional Partners:
PPP2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B’’ subunit beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; EF-hand domain containing (575 aa)
       
      0.811
MORN1
MORN repeat containing 1 (497 aa)
           
  0.799
TBCC
Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family (346 aa)
           
  0.669
PPP2CB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase; Protein phosphatase catalytic subunits (309 aa)
       
      0.663
GFOD2
Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly (385 aa)
           
  0.613
KRBA1
Protein KRBA1; KRAB-A domain containing 1 (1030 aa)
       
      0.588
YTHDF1
YTH domain-containing family protein 1; Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency. M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA translation efficiency- promotes ribosome loading to m6A- containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (559 aa)
           
  0.585
TBCD
Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epi [...] (1192 aa)
           
  0.556
DNAJB7
DnaJ homolog subfamily B member 7; Probably acts as a co-chaperone; DNAJ heat shock proteins (309 aa)
           
  0.549
LURAP1L
Leucine rich adaptor protein 1 like (228 aa)
       
      0.544
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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