| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ELMOD2 | INPP4B | ENSP00000326342 | ENSP00000425487 | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | Type II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | 0.658 |
| ELMOD2 | PPME1 | ENSP00000326342 | ENSP00000381461 | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme; Protein phosphatase 2 modulatory subunits | 0.705 |
| ELMOD2 | TBC1D9 | ENSP00000326342 | ENSP00000411197 | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | 0.866 |
| ELMOD2 | TBC1D9B | ENSP00000326342 | ENSP00000349291 | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | TBC1 domain family member 9B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | 0.454 |
| INPP4B | ELMOD2 | ENSP00000425487 | ENSP00000326342 | Type II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | 0.658 |
| INPP4B | PPME1 | ENSP00000425487 | ENSP00000381461 | Type II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme; Protein phosphatase 2 modulatory subunits | 0.439 |
| INPP4B | TBC1D9 | ENSP00000425487 | ENSP00000411197 | Type II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | 0.665 |
| INPP4B | TBC1D9B | ENSP00000425487 | ENSP00000349291 | Type II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | TBC1 domain family member 9B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | 0.514 |
| LANCL1 | TBC1D9 | ENSP00000388713 | ENSP00000411197 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | 0.692 |
| LANCL1 | TBC1D9B | ENSP00000388713 | ENSP00000349291 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | TBC1 domain family member 9B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | 0.558 |
| PPME1 | ELMOD2 | ENSP00000381461 | ENSP00000326342 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme; Protein phosphatase 2 modulatory subunits | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses | 0.705 |
| PPME1 | INPP4B | ENSP00000381461 | ENSP00000425487 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme; Protein phosphatase 2 modulatory subunits | Type II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate | 0.439 |
| PPME1 | TBC1D9 | ENSP00000381461 | ENSP00000411197 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme; Protein phosphatase 2 modulatory subunits | TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | 0.702 |
| SGSM1 | TBC1D20 | ENSP00000383212 | ENSP00000346139 | Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude | 0.464 |
| SGSM1 | TBC1D21 | ENSP00000383212 | ENSP00000300504 | Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | 0.506 |
| SGSM1 | TBC1D7 | ENSP00000383212 | ENSP00000475727 | Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family | TBC1 domain family member 7; Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is un [...] | 0.564 |
| SGSM1 | TBC1D9 | ENSP00000383212 | ENSP00000411197 | Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family | TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | 0.660 |
| SGSM1 | TBC1D9B | ENSP00000383212 | ENSP00000349291 | Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family | TBC1 domain family member 9B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | 0.540 |
| SGSM2 | TBC1D20 | ENSP00000268989 | ENSP00000346139 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation; Belongs to the RUTBC family | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude | 0.501 |
| SGSM2 | TBC1D21 | ENSP00000268989 | ENSP00000300504 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation; Belongs to the RUTBC family | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | 0.456 |
