| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KCNG4 | KIAA1462 | ENSP00000312129 | ENSP00000364526 | Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily | Junctional protein associated with coronary artery disease; KIAA1462 | 0.502 |
| KCNG4 | SDK2 | ENSP00000312129 | ENSP00000376421 | Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | 0.506 |
| KCNG4 | ZNF799 | ENSP00000312129 | ENSP00000411084 | Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.477 |
| KIAA1462 | KCNG4 | ENSP00000364526 | ENSP00000312129 | Junctional protein associated with coronary artery disease; KIAA1462 | Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily | 0.502 |
| KIAA1462 | SDK2 | ENSP00000364526 | ENSP00000376421 | Junctional protein associated with coronary artery disease; KIAA1462 | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | 0.575 |
| KIAA1462 | ZNF799 | ENSP00000364526 | ENSP00000411084 | Junctional protein associated with coronary artery disease; KIAA1462 | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.557 |
| RPL14 | ZNF799 | ENSP00000379506 | ENSP00000411084 | 60S ribosomal protein L14; Component of the large ribosomal subunit; Belongs to the eukaryotic ribosomal protein eL14 family | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.413 |
| SDK2 | KCNG4 | ENSP00000376421 | ENSP00000312129 | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily | 0.506 |
| SDK2 | KIAA1462 | ENSP00000376421 | ENSP00000364526 | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | Junctional protein associated with coronary artery disease; KIAA1462 | 0.575 |
| SDK2 | ZNF799 | ENSP00000376421 | ENSP00000411084 | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.481 |
| TRIM28 | ZNF799 | ENSP00000253024 | ENSP00000411084 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.918 |
| ZNF799 | KCNG4 | ENSP00000411084 | ENSP00000312129 | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily | 0.477 |
| ZNF799 | KIAA1462 | ENSP00000411084 | ENSP00000364526 | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Junctional protein associated with coronary artery disease; KIAA1462 | 0.557 |
| ZNF799 | RPL14 | ENSP00000411084 | ENSP00000379506 | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 60S ribosomal protein L14; Component of the large ribosomal subunit; Belongs to the eukaryotic ribosomal protein eL14 family | 0.413 |
| ZNF799 | SDK2 | ENSP00000411084 | ENSP00000376421 | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing | 0.481 |
| ZNF799 | TRIM28 | ENSP00000411084 | ENSP00000253024 | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.918 |
