| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C19orf45 | ZNF783 | ENSP00000355241 | ENSP00000410890 | Testis-expressed protein 45; Chromosome 19 open reading frame 45 | Protein ZNF783; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.669 |
| CHORDC1 | NFE2L3 | ENSP00000319255 | ENSP00000056233 | Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | 0.482 |
| CHORDC1 | RIMKLB | ENSP00000319255 | ENSP00000350136 | Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis | Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate | 0.573 |
| CHORDC1 | SLITRK5 | ENSP00000319255 | ENSP00000366283 | Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis | SLIT and NTRK-like protein 5; Suppresses neurite outgrowth; Belongs to the SLITRK family | 0.493 |
| CHORDC1 | ZNF783 | ENSP00000319255 | ENSP00000410890 | Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis | Protein ZNF783; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.674 |
| EXOSC5 | RPL39L | ENSP00000221233 | ENSP00000296277 | Exosome complex component RRP46; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | Ribosomal protein L39 like; Belongs to the eukaryotic ribosomal protein eL39 family | 0.902 |
| EXOSC5 | ZNF783 | ENSP00000221233 | ENSP00000410890 | Exosome complex component RRP46; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | Protein ZNF783; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.546 |
| H1FX | ZNF783 | ENSP00000329662 | ENSP00000410890 | Histone H1x; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | Protein ZNF783; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.482 |
| NFE2L3 | CHORDC1 | ENSP00000056233 | ENSP00000319255 | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis | 0.482 |
| NFE2L3 | RIMKLB | ENSP00000056233 | ENSP00000350136 | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate | 0.432 |
| NFE2L3 | ZNF783 | ENSP00000056233 | ENSP00000410890 | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | Protein ZNF783; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.533 |
| PRDM7 | ZNF783 | ENSP00000396732 | ENSP00000410890 | Probable histone-lysine N-methyltransferase PRDM7; Probable histone methyltransferase; PR/SET domain family | Protein ZNF783; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.542 |
| RIMKLB | CHORDC1 | ENSP00000350136 | ENSP00000319255 | Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate | Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis | 0.573 |
| RIMKLB | NFE2L3 | ENSP00000350136 | ENSP00000056233 | Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins | 0.432 |
| RIMKLB | SLITRK5 | ENSP00000350136 | ENSP00000366283 | Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate | SLIT and NTRK-like protein 5; Suppresses neurite outgrowth; Belongs to the SLITRK family | 0.540 |
| RIMKLB | ZNF783 | ENSP00000350136 | ENSP00000410890 | Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate | Protein ZNF783; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.685 |
| RPL39L | EXOSC5 | ENSP00000296277 | ENSP00000221233 | Ribosomal protein L39 like; Belongs to the eukaryotic ribosomal protein eL39 family | Exosome complex component RRP46; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | 0.902 |
| RPL39L | ZNF783 | ENSP00000296277 | ENSP00000410890 | Ribosomal protein L39 like; Belongs to the eukaryotic ribosomal protein eL39 family | Protein ZNF783; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.476 |
| SLITRK5 | CHORDC1 | ENSP00000366283 | ENSP00000319255 | SLIT and NTRK-like protein 5; Suppresses neurite outgrowth; Belongs to the SLITRK family | Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis | 0.493 |
| SLITRK5 | RIMKLB | ENSP00000366283 | ENSP00000350136 | SLIT and NTRK-like protein 5; Suppresses neurite outgrowth; Belongs to the SLITRK family | Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate | 0.540 |
