| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC169 | ZNF562 | ENSP00000426174 | ENSP00000410734 | Coiled-coil domain containing 169 | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.658 |
| CRACR2A | ZNF562 | ENSP00000409382 | ENSP00000410734 | EF-hand calcium-binding domain-containing protein 4B; Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from OR [...] | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.589 |
| OBFC1 | ZNF562 | ENSP00000224950 | ENSP00000410734 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.428 |
| TRIM28 | ZNF561 | ENSP00000253024 | ENSP00000303915 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.903 |
| TRIM28 | ZNF562 | ENSP00000253024 | ENSP00000410734 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.903 |
| TYW3 | ZNF562 | ENSP00000359904 | ENSP00000410734 | tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity); Belongs to the TYW3 family | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.418 |
| ZNF561 | TRIM28 | ENSP00000303915 | ENSP00000253024 | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.903 |
| ZNF561 | ZNF562 | ENSP00000303915 | ENSP00000410734 | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.636 |
| ZNF562 | CCDC169 | ENSP00000410734 | ENSP00000426174 | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Coiled-coil domain containing 169 | 0.658 |
| ZNF562 | CRACR2A | ENSP00000410734 | ENSP00000409382 | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | EF-hand calcium-binding domain-containing protein 4B; Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from OR [...] | 0.589 |
| ZNF562 | OBFC1 | ENSP00000410734 | ENSP00000224950 | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | 0.428 |
| ZNF562 | TRIM28 | ENSP00000410734 | ENSP00000253024 | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.903 |
| ZNF562 | TYW3 | ENSP00000410734 | ENSP00000359904 | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity); Belongs to the TYW3 family | 0.418 |
| ZNF562 | ZNF561 | ENSP00000410734 | ENSP00000303915 | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.636 |
