ZSCAN2 protein (human) - STRING database

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ZSCAN2

Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis; SCAN domain containing (614 aa)

Predicted Functional Partners:

KNDC1

0.562

TMEM147

0.512

FEM1B

0.508

C7orf25

0.472

WDR73

0.466

UTF1

0.465

TM4SF20

0.463

DEFB129

0.452

TMBIM4

0.448

CIZ1

0.447

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C7orf25	ZSCAN2	ENSP00000413029	ENSP00000410198	UPF0415 protein C7orf25; Chromosome 7 open reading frame 25; Belongs to the UPF0415 family	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis; SCAN domain containing	0.472
CIZ1	ZSCAN2	ENSP00000439244	ENSP00000410198	Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis; SCAN domain containing	0.447
DEFB129	TM4SF20	ENSP00000246105	ENSP00000303028	Beta-defensin 129; Has antibacterial activity; Defensins, beta	Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...]	0.510
DEFB129	TMBIM4	ENSP00000246105	ENSP00000286424	Beta-defensin 129; Has antibacterial activity; Defensins, beta	Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family	0.480
DEFB129	TMEM147	ENSP00000246105	ENSP00000222284	Beta-defensin 129; Has antibacterial activity; Defensins, beta	Transmembrane protein 147	0.596
DEFB129	ZSCAN2	ENSP00000246105	ENSP00000410198	Beta-defensin 129; Has antibacterial activity; Defensins, beta	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis; SCAN domain containing	0.452
FEM1B	ZSCAN2	ENSP00000307298	ENSP00000410198	Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1; Belongs to the fem-1 family	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis; SCAN domain containing	0.508
KNDC1	UTF1	ENSP00000304437	ENSP00000305906	Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence	Undifferentiated embryonic cell transcription factor 1; Acts as a transcriptional coactivator of ATF2	0.408
KNDC1	ZSCAN2	ENSP00000304437	ENSP00000410198	Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis; SCAN domain containing	0.562
TM4SF20	DEFB129	ENSP00000303028	ENSP00000246105	Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...]	Beta-defensin 129; Has antibacterial activity; Defensins, beta	0.510
TM4SF20	TMBIM4	ENSP00000303028	ENSP00000286424	Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...]	Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family	0.492
TM4SF20	TMEM147	ENSP00000303028	ENSP00000222284	Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...]	Transmembrane protein 147	0.516
TM4SF20	ZSCAN2	ENSP00000303028	ENSP00000410198	Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...]	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis; SCAN domain containing	0.463
TMBIM4	DEFB129	ENSP00000286424	ENSP00000246105	Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family	Beta-defensin 129; Has antibacterial activity; Defensins, beta	0.480
TMBIM4	TM4SF20	ENSP00000286424	ENSP00000303028	Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family	Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...]	0.492
TMBIM4	TMEM147	ENSP00000286424	ENSP00000222284	Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family	Transmembrane protein 147	0.515
TMBIM4	ZSCAN2	ENSP00000286424	ENSP00000410198	Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family	Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis; SCAN domain containing	0.448
TMEM147	DEFB129	ENSP00000222284	ENSP00000246105	Transmembrane protein 147	Beta-defensin 129; Has antibacterial activity; Defensins, beta	0.596
TMEM147	TM4SF20	ENSP00000222284	ENSP00000303028	Transmembrane protein 147	Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ’regulated alternative translocation’ (RAT) and regulates the function of the transmembrane protein; Bel [...]	0.516
TMEM147	TMBIM4	ENSP00000222284	ENSP00000286424	Transmembrane protein 147	Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family	0.515

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