node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CREB5 | ZNF740 | ENSP00000350359 | ENSP00000409463 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription; Basic leucine zipper proteins | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.630 |
DNAJC5B | PDE7A | ENSP00000276570 | ENSP00000385632 | DnaJ heat shock protein family member C5 beta | High affinity cAMP-specific 3’,5’-cyclic phosphodiesterase 7A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction; Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily | 0.629 |
DNAJC5B | ZNF740 | ENSP00000276570 | ENSP00000409463 | DnaJ heat shock protein family member C5 beta | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.650 |
IFNG | PDE6B | ENSP00000229135 | ENSP00000420295 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family | Rod cGMP-specific 3’,5’-cyclic phosphodiesterase subunit beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme; Belongs to the cyclic nucleotide phosphodiesterase family | 0.511 |
IFNG | ZNF740 | ENSP00000229135 | ENSP00000409463 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.680 |
PDE6B | IFNG | ENSP00000420295 | ENSP00000229135 | Rod cGMP-specific 3’,5’-cyclic phosphodiesterase subunit beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme; Belongs to the cyclic nucleotide phosphodiesterase family | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family | 0.511 |
PDE6B | ZNF740 | ENSP00000420295 | ENSP00000409463 | Rod cGMP-specific 3’,5’-cyclic phosphodiesterase subunit beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme; Belongs to the cyclic nucleotide phosphodiesterase family | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.690 |
PDE7A | DNAJC5B | ENSP00000385632 | ENSP00000276570 | High affinity cAMP-specific 3’,5’-cyclic phosphodiesterase 7A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction; Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily | DnaJ heat shock protein family member C5 beta | 0.629 |
PDE7A | ZNF740 | ENSP00000385632 | ENSP00000409463 | High affinity cAMP-specific 3’,5’-cyclic phosphodiesterase 7A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction; Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.667 |
PFDN5 | SPRYD3 | ENSP00000447942 | ENSP00000301463 | Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC; Belongs to the prefoldin subunit alpha family | SPRY domain containing 3 | 0.648 |
PFDN5 | ZNF740 | ENSP00000447942 | ENSP00000409463 | Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC; Belongs to the prefoldin subunit alpha family | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.610 |
REEP5 | TBRG1 | ENSP00000368959 | ENSP00000409016 | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family | Transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability; Belongs to the TBRG1 family | 0.666 |
REEP5 | ZNF740 | ENSP00000368959 | ENSP00000409463 | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.640 |
SPRYD3 | PFDN5 | ENSP00000301463 | ENSP00000447942 | SPRY domain containing 3 | Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC; Belongs to the prefoldin subunit alpha family | 0.648 |
SPRYD3 | ZNF740 | ENSP00000301463 | ENSP00000409463 | SPRY domain containing 3 | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.704 |
TBRG1 | REEP5 | ENSP00000409016 | ENSP00000368959 | Transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability; Belongs to the TBRG1 family | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family | 0.666 |
TBRG1 | ZNF740 | ENSP00000409016 | ENSP00000409463 | Transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability; Belongs to the TBRG1 family | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.707 |
TRIM28 | ZNF740 | ENSP00000253024 | ENSP00000409463 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.904 |
ZNF740 | CREB5 | ENSP00000409463 | ENSP00000350359 | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription; Basic leucine zipper proteins | 0.630 |
ZNF740 | DNAJC5B | ENSP00000409463 | ENSP00000276570 | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type | DnaJ heat shock protein family member C5 beta | 0.650 |