| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASRGL1 | KIAA2013 | ENSP00000400057 | ENSP00000365756 | Isoaspartyl peptidase/L-asparaginase; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activ [...] | Uncharacterized protein KIAA2013; KIAA2013 | 0.679 |
| ASRGL1 | MYO1D | ENSP00000400057 | ENSP00000324527 | Isoaspartyl peptidase/L-asparaginase; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activ [...] | Unconventional myosin-Id; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity); Myosins, class I | 0.658 |
| ASRGL1 | OTUD4 | ENSP00000400057 | ENSP00000409279 | Isoaspartyl peptidase/L-asparaginase; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activ [...] | OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing | 0.657 |
| ASRGL1 | PARP11 | ENSP00000400057 | ENSP00000228820 | Isoaspartyl peptidase/L-asparaginase; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activ [...] | Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases | 0.606 |
| ASRGL1 | RCC2 | ENSP00000400057 | ENSP00000364585 | Isoaspartyl peptidase/L-asparaginase; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activ [...] | Protein RCC2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 | 0.663 |
| C4orf51 | OTUD4 | ENSP00000391404 | ENSP00000409279 | Uncharacterized protein C4orf51; Chromosome 4 open reading frame 51 | OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing | 0.659 |
| KIAA2013 | ASRGL1 | ENSP00000365756 | ENSP00000400057 | Uncharacterized protein KIAA2013; KIAA2013 | Isoaspartyl peptidase/L-asparaginase; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activ [...] | 0.679 |
| KIAA2013 | MYO1D | ENSP00000365756 | ENSP00000324527 | Uncharacterized protein KIAA2013; KIAA2013 | Unconventional myosin-Id; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity); Myosins, class I | 0.654 |
| KIAA2013 | OTUD4 | ENSP00000365756 | ENSP00000409279 | Uncharacterized protein KIAA2013; KIAA2013 | OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing | 0.701 |
| KIAA2013 | PARP11 | ENSP00000365756 | ENSP00000228820 | Uncharacterized protein KIAA2013; KIAA2013 | Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases | 0.697 |
| KIAA2013 | RCC2 | ENSP00000365756 | ENSP00000364585 | Uncharacterized protein KIAA2013; KIAA2013 | Protein RCC2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 | 0.696 |
| MYO1D | ASRGL1 | ENSP00000324527 | ENSP00000400057 | Unconventional myosin-Id; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity); Myosins, class I | Isoaspartyl peptidase/L-asparaginase; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activ [...] | 0.658 |
| MYO1D | KIAA2013 | ENSP00000324527 | ENSP00000365756 | Unconventional myosin-Id; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity); Myosins, class I | Uncharacterized protein KIAA2013; KIAA2013 | 0.654 |
| MYO1D | OTUD4 | ENSP00000324527 | ENSP00000409279 | Unconventional myosin-Id; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity); Myosins, class I | OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing | 0.656 |
| MYO1D | PARP11 | ENSP00000324527 | ENSP00000228820 | Unconventional myosin-Id; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity); Myosins, class I | Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases | 0.620 |
| MYO1D | RCC2 | ENSP00000324527 | ENSP00000364585 | Unconventional myosin-Id; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity); Myosins, class I | Protein RCC2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 | 0.661 |
| NANOS1 | OTUD4 | ENSP00000393275 | ENSP00000409279 | Nanos homolog 1; May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3’-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion; Belongs to the nanos family | OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing | 0.673 |
| OTUD4 | ASRGL1 | ENSP00000409279 | ENSP00000400057 | OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing | Isoaspartyl peptidase/L-asparaginase; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activ [...] | 0.657 |
| OTUD4 | C4orf51 | ENSP00000409279 | ENSP00000391404 | OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing | Uncharacterized protein C4orf51; Chromosome 4 open reading frame 51 | 0.659 |
| OTUD4 | KIAA2013 | ENSP00000409279 | ENSP00000365756 | OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes ’Lys-48’-linked polyubiquitin; OTU domain containing | Uncharacterized protein KIAA2013; KIAA2013 | 0.701 |
