node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR10 | ACTR1A | ENSP00000254286 | ENSP00000358921 | Actin related protein 10 homolog; Belongs to the actin family | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.996 |
ACTR10 | ACTR1B | ENSP00000254286 | ENSP00000289228 | Actin related protein 10 homolog; Belongs to the actin family | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.995 |
ACTR10 | DCTN1 | ENSP00000254286 | ENSP00000354791 | Actin related protein 10 homolog; Belongs to the actin family | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.997 |
ACTR10 | DCTN2 | ENSP00000254286 | ENSP00000408910 | Actin related protein 10 homolog; Belongs to the actin family | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin | 0.998 |
ACTR10 | DCTN3 | ENSP00000254286 | ENSP00000259632 | Actin related protein 10 homolog; Belongs to the actin family | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis; Dynactin | 0.974 |
ACTR10 | DCTN4 | ENSP00000254286 | ENSP00000414906 | Actin related protein 10 homolog; Belongs to the actin family | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | 0.998 |
ACTR10 | DCTN5 | ENSP00000254286 | ENSP00000300087 | Actin related protein 10 homolog; Belongs to the actin family | Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily | 0.985 |
ACTR10 | DCTN6 | ENSP00000254286 | ENSP00000221114 | Actin related protein 10 homolog; Belongs to the actin family | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily | 0.998 |
ACTR10 | DYNC1H1 | ENSP00000254286 | ENSP00000348965 | Actin related protein 10 homolog; Belongs to the actin family | Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression; Belongs to the dynein heavy chain family | 0.980 |
ACTR10 | DYNC1I2 | ENSP00000254286 | ENSP00000380308 | Actin related protein 10 homolog; Belongs to the actin family | Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes | 0.958 |
ACTR1A | ACTR10 | ENSP00000358921 | ENSP00000254286 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Actin related protein 10 homolog; Belongs to the actin family | 0.996 |
ACTR1A | ACTR1B | ENSP00000358921 | ENSP00000289228 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | 0.985 |
ACTR1A | DCTN1 | ENSP00000358921 | ENSP00000354791 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.998 |
ACTR1A | DCTN2 | ENSP00000358921 | ENSP00000408910 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Dynactin | 0.999 |
ACTR1A | DCTN3 | ENSP00000358921 | ENSP00000259632 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis; Dynactin | 0.946 |
ACTR1A | DCTN4 | ENSP00000358921 | ENSP00000414906 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | 0.996 |
ACTR1A | DCTN5 | ENSP00000358921 | ENSP00000300087 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily | 0.999 |
ACTR1A | DCTN6 | ENSP00000358921 | ENSP00000221114 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily | 0.999 |
ACTR1A | DYNC1H1 | ENSP00000358921 | ENSP00000348965 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression; Belongs to the dynein heavy chain family | 0.997 |
ACTR1A | DYNC1I2 | ENSP00000358921 | ENSP00000380308 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins | Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes | 0.983 |