| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COA1 | GLB1L2 | ENSP00000379218 | ENSP00000444628 | Cytochrome c oxidase assembly factor 1 homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV | Beta-galactosidase-1-like protein 2; Galactosidase beta 1 like 2 | 0.472 |
| COA1 | PABPN1L | ENSP00000379218 | ENSP00000408598 | Cytochrome c oxidase assembly factor 1 homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV | Embryonic polyadenylate-binding protein 2; Binds the poly(A) tail of mRNA; RNA binding motif containing | 0.556 |
| CSTF2 | CSTF2T | ENSP00000362063 | ENSP00000332444 | Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | Cleavage stimulation factor subunit 2 tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity); Cleavage stimulation factor subunits | 0.988 |
| CSTF2 | ENSG00000258643 | ENSP00000362063 | ENSP00000452479 | Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | BCL2L2-PABPN1 readthrough; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX | 0.628 |
| CSTF2 | PABPN1 | ENSP00000362063 | ENSP00000216727 | Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | Polyadenylate-binding protein 2; Involved in the 3’-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense- mediated decay (NMD) of mRNA. Cooperates with SKIP to syner [...] | 0.969 |
| CSTF2 | PABPN1L | ENSP00000362063 | ENSP00000408598 | Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | Embryonic polyadenylate-binding protein 2; Binds the poly(A) tail of mRNA; RNA binding motif containing | 0.605 |
| CSTF2T | CSTF2 | ENSP00000332444 | ENSP00000362063 | Cleavage stimulation factor subunit 2 tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity); Cleavage stimulation factor subunits | Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | 0.988 |
| CSTF2T | ENSG00000258643 | ENSP00000332444 | ENSP00000452479 | Cleavage stimulation factor subunit 2 tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity); Cleavage stimulation factor subunits | BCL2L2-PABPN1 readthrough; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX | 0.628 |
| CSTF2T | PABPN1 | ENSP00000332444 | ENSP00000216727 | Cleavage stimulation factor subunit 2 tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity); Cleavage stimulation factor subunits | Polyadenylate-binding protein 2; Involved in the 3’-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense- mediated decay (NMD) of mRNA. Cooperates with SKIP to syner [...] | 0.963 |
| CSTF2T | PABPN1L | ENSP00000332444 | ENSP00000408598 | Cleavage stimulation factor subunit 2 tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity); Cleavage stimulation factor subunits | Embryonic polyadenylate-binding protein 2; Binds the poly(A) tail of mRNA; RNA binding motif containing | 0.606 |
| ENSG00000258643 | CSTF2 | ENSP00000452479 | ENSP00000362063 | BCL2L2-PABPN1 readthrough; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX | Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3’-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity) | 0.628 |
| ENSG00000258643 | CSTF2T | ENSP00000452479 | ENSP00000332444 | BCL2L2-PABPN1 readthrough; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX | Cleavage stimulation factor subunit 2 tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity); Cleavage stimulation factor subunits | 0.628 |
| ENSG00000258643 | PABPN1 | ENSP00000452479 | ENSP00000216727 | BCL2L2-PABPN1 readthrough; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX | Polyadenylate-binding protein 2; Involved in the 3’-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense- mediated decay (NMD) of mRNA. Cooperates with SKIP to syner [...] | 0.959 |
| ENSG00000258643 | PABPN1L | ENSP00000452479 | ENSP00000408598 | BCL2L2-PABPN1 readthrough; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX | Embryonic polyadenylate-binding protein 2; Binds the poly(A) tail of mRNA; RNA binding motif containing | 0.805 |
| ENSG00000258643 | UBE2I | ENSP00000452479 | ENSP00000348056 | BCL2L2-PABPN1 readthrough; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at ’Lys-386’; Belongs to the ubiquitin-conjugating enzyme family | 0.670 |
| GLB1L2 | COA1 | ENSP00000444628 | ENSP00000379218 | Beta-galactosidase-1-like protein 2; Galactosidase beta 1 like 2 | Cytochrome c oxidase assembly factor 1 homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV | 0.472 |
| GLB1L2 | PABPN1L | ENSP00000444628 | ENSP00000408598 | Beta-galactosidase-1-like protein 2; Galactosidase beta 1 like 2 | Embryonic polyadenylate-binding protein 2; Binds the poly(A) tail of mRNA; RNA binding motif containing | 0.553 |
| PABPC1L | PABPN1 | ENSP00000255136 | ENSP00000216727 | Polyadenylate-binding protein 1-like; poly(A) binding protein cytoplasmic 1 like; RNA binding motif containing | Polyadenylate-binding protein 2; Involved in the 3’-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense- mediated decay (NMD) of mRNA. Cooperates with SKIP to syner [...] | 0.500 |
| PABPC1L | PABPN1L | ENSP00000255136 | ENSP00000408598 | Polyadenylate-binding protein 1-like; poly(A) binding protein cytoplasmic 1 like; RNA binding motif containing | Embryonic polyadenylate-binding protein 2; Binds the poly(A) tail of mRNA; RNA binding motif containing | 0.687 |
| PABPC3 | PABPN1 | ENSP00000281589 | ENSP00000216727 | Polyadenylate-binding protein 3; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1; RNA binding motif containing | Polyadenylate-binding protein 2; Involved in the 3’-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense- mediated decay (NMD) of mRNA. Cooperates with SKIP to syner [...] | 0.705 |
