• Version:
  • 11.0 [archived version]
STRINGSTRING
SARS SARS SARS2 SARS2 METTL6 METTL6 ZNRF2 ZNRF2 RSPRY1 RSPRY1 EAF1 EAF1 GPATCH3 GPATCH3 FKBP14 FKBP14 EFCAB1 EFCAB1 FAM192A FAM192A SNX20 SNX20
"METTL6" - Methyltransferase-like protein 6 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
METTL6Methyltransferase-like protein 6; Probable methyltransferase (284 aa)    
Predicted Functional Partners:
EAF1
ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities; Belongs to the EAF family (268 aa)
     
   
  0.825
SARS
Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction- serine is first activated by ATP to form Ser- AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at ’Lys-16’ (H4K16) [...] (514 aa)
     
   
  0.812
RSPRY1
Ring finger and SPRY domain containing 1 (576 aa)
           
  0.791
EFCAB1
EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1 (211 aa)
           
  0.791
FAM192A
Protein FAM192A; Family with sequence similarity 192 member A (254 aa)
     
   
  0.779
GPATCH3
G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6; G [...] (525 aa)
           
  0.753
SNX20
Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion (316 aa)
           
  0.752
SARS2
Serine--tRNA ligase, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec); Aminoacyl tRNA synthetases, Class II (520 aa)
     
   
  0.743
ZNRF2
E3 ubiquitin-protein ligase ZNRF2; May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Ring finger proteins (242 aa)
     
   
  0.736
FKBP14
Peptidyl-prolyl cis-trans isomerase FKBP14; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing (211 aa)
     
   
  0.724
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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