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  • 11.0 [archived version]
STRINGSTRING
SLC25A35 SLC25A35 MRPL47 MRPL47 IMPDH2 IMPDH2 KCNK17 KCNK17 SLC25A44 SLC25A44 PMF1-BGLAP PMF1-BGLAP MEF2BNB MEF2BNB PMF1 PMF1 FAM151B FAM151B GOLGA7 GOLGA7 TLCD1 TLCD1
"SLC25A44" - Solute carrier family 25 member 44 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC25A44Solute carrier family 25 member 44 (322 aa)    
Predicted Functional Partners:
IMPDH2
Inosine-5’-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (514 aa)
       
      0.847
PMF1
Polyamine-modulated factor 1; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT (207 aa)
           
  0.745
SLC25A35
Solute carrier family 25 member 35; Belongs to the mitochondrial carrier (TC 2.A.29) family (295 aa)
           
  0.664
MRPL47
Mitochondrial ribosomal protein L47 (250 aa)
           
  0.660
PMF1-BGLAP
Polyamine-modulated factor 1; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT (220 aa)
           
  0.630
KCNK17
Potassium channel subfamily K member 17; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K (332 aa)
           
  0.609
TLCD1
Calfacilitin; Calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CACNA1C/CaV1.2 channel. Regulation of intracellular calcium by Calfacilitin is required for neural plate formation (By similarity); TLC domain containing (247 aa)
           
  0.581
FAM151B
Protein FAM151B; Family with sequence similarity 151 member B (276 aa)
           
  0.577
MEF2BNB
BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (119 aa)
           
  0.566
GOLGA7
Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (137 aa)
           
  0.556
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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