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  • 11.0 [archived version]
STRINGSTRING
FAM20A FAM20A FJX1 FJX1 FAM20B FAM20B FAM20C FAM20C FAM198A FAM198A PI4K2A PI4K2A IKBIP IKBIP ARMC7 ARMC7 LSG1 LSG1 HEXDC HEXDC ZNF662 ZNF662
"FAM198A" - Protein FAM198A in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
FAM198AProtein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family (575 aa)    
Predicted Functional Partners:
FAM20A
Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the ’matrix’ that guides the deposition of the enamel minerals (541 aa)
     
   
  0.864
FAM20B
Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalyt [...] (409 aa)
           
  0.832
FJX1
Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching; Belongs to the FJX1/FJ family (437 aa)
           
  0.784
FAM20C
Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] (584 aa)
     
   
  0.781
ZNF662
Zinc finger protein 662; Zinc fingers C2H2-type (452 aa)
           
  0.663
ARMC7
Armadillo repeat containing 7 (198 aa)
           
  0.622
HEXDC
Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family (585 aa)
           
  0.580
IKBIP
IKBKB interacting protein (377 aa)
           
  0.516
LSG1
Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable) (658 aa)
           
  0.507
PI4K2A
Phosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4- kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second mess [...] (479 aa)
           
  0.479
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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