node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC7 | FAM198A | ENSP00000245543 | ENSP00000407301 | Armadillo repeat containing 7 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | 0.622 |
ARMC7 | HEXDC | ENSP00000245543 | ENSP00000337854 | Armadillo repeat containing 7 | Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family | 0.565 |
ARMC7 | IKBIP | ENSP00000245543 | ENSP00000299157 | Armadillo repeat containing 7 | IKBKB interacting protein | 0.440 |
ARMC7 | LSG1 | ENSP00000245543 | ENSP00000265245 | Armadillo repeat containing 7 | Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable) | 0.501 |
ARMC7 | ZNF662 | ENSP00000245543 | ENSP00000329264 | Armadillo repeat containing 7 | Zinc finger protein 662; Zinc fingers C2H2-type | 0.650 |
FAM198A | ARMC7 | ENSP00000407301 | ENSP00000245543 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Armadillo repeat containing 7 | 0.622 |
FAM198A | FAM20A | ENSP00000407301 | ENSP00000468308 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the ’matrix’ that guides the deposition of the enamel minerals | 0.864 |
FAM198A | FAM20B | ENSP00000407301 | ENSP00000263733 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalyt [...] | 0.832 |
FAM198A | FAM20C | ENSP00000407301 | ENSP00000322323 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] | 0.781 |
FAM198A | FJX1 | ENSP00000407301 | ENSP00000400223 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching; Belongs to the FJX1/FJ family | 0.784 |
FAM198A | HEXDC | ENSP00000407301 | ENSP00000337854 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family | 0.580 |
FAM198A | IKBIP | ENSP00000407301 | ENSP00000299157 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | IKBKB interacting protein | 0.516 |
FAM198A | LSG1 | ENSP00000407301 | ENSP00000265245 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable) | 0.507 |
FAM198A | PI4K2A | ENSP00000407301 | ENSP00000359665 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Phosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4- kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second mess [...] | 0.479 |
FAM198A | ZNF662 | ENSP00000407301 | ENSP00000329264 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Zinc finger protein 662; Zinc fingers C2H2-type | 0.663 |
FAM20A | FAM198A | ENSP00000468308 | ENSP00000407301 | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the ’matrix’ that guides the deposition of the enamel minerals | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | 0.864 |
FAM20A | FAM20C | ENSP00000468308 | ENSP00000322323 | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the ’matrix’ that guides the deposition of the enamel minerals | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] | 0.988 |
FAM20A | FJX1 | ENSP00000468308 | ENSP00000400223 | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the ’matrix’ that guides the deposition of the enamel minerals | Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching; Belongs to the FJX1/FJ family | 0.708 |
FAM20B | FAM198A | ENSP00000263733 | ENSP00000407301 | Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalyt [...] | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | 0.832 |
FAM20B | FJX1 | ENSP00000263733 | ENSP00000400223 | Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalyt [...] | Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching; Belongs to the FJX1/FJ family | 0.719 |