IQCA1 protein (human) - STRING database

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IQCA1

IQ motif containing with AAA domain 1 (830 aa)

Predicted Functional Partners:

IQCG

0.819

IQCD

0.771

UBXN7

0.758

EFCAB2

0.747

TCTE1

0.717

CCDC135

0.702

ARL14

0.702

DTL

0.688

CCDC39

0.666

GAS8

0.664

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL14	IQCA1	ENSP00000323847	ENSP00000407213	ADP-ribosylation factor-like protein 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells; ARF GTPase family	IQ motif containing with AAA domain 1	0.702
CCDC135	CCDC39	ENSP00000353942	ENSP00000405708	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly	0.515
CCDC135	EFCAB2	ENSP00000353942	ENSP00000355480	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	EF-hand calcium-binding domain-containing protein 2; EF-hand calcium binding domain 2; Cilia and flagella associated	0.625
CCDC135	GAS8	ENSP00000353942	ENSP00000268699	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	Growth arrest-specific protein 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). May play a role in cilia motility; Dynein regulatory complex	0.719
CCDC135	IQCA1	ENSP00000353942	ENSP00000407213	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	IQ motif containing with AAA domain 1	0.702
CCDC135	IQCD	ENSP00000353942	ENSP00000299732	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	IQ domain-containing protein D; Cilia and flagella associated	0.753
CCDC135	IQCG	ENSP00000353942	ENSP00000265239	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	IQ domain-containing protein G; Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin- dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility	0.591
CCDC135	TCTE1	ENSP00000353942	ENSP00000360560	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	T-complex-associated-testis-expressed 1; Dynein regulatory complex	0.680
CCDC39	CCDC135	ENSP00000405708	ENSP00000353942	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	0.515
CCDC39	GAS8	ENSP00000405708	ENSP00000268699	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly	Growth arrest-specific protein 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). May play a role in cilia motility; Dynein regulatory complex	0.817
CCDC39	IQCA1	ENSP00000405708	ENSP00000407213	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly	IQ motif containing with AAA domain 1	0.666
CCDC39	TCTE1	ENSP00000405708	ENSP00000360560	Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly	T-complex-associated-testis-expressed 1; Dynein regulatory complex	0.536
DTL	IQCA1	ENSP00000355958	ENSP00000407213	Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replicati [...]	IQ motif containing with AAA domain 1	0.688
EFCAB2	CCDC135	ENSP00000355480	ENSP00000353942	EF-hand calcium-binding domain-containing protein 2; EF-hand calcium binding domain 2; Cilia and flagella associated	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	0.625
EFCAB2	GAS8	ENSP00000355480	ENSP00000268699	EF-hand calcium-binding domain-containing protein 2; EF-hand calcium binding domain 2; Cilia and flagella associated	Growth arrest-specific protein 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). May play a role in cilia motility; Dynein regulatory complex	0.458
EFCAB2	IQCA1	ENSP00000355480	ENSP00000407213	EF-hand calcium-binding domain-containing protein 2; EF-hand calcium binding domain 2; Cilia and flagella associated	IQ motif containing with AAA domain 1	0.747
EFCAB2	IQCD	ENSP00000355480	ENSP00000299732	EF-hand calcium-binding domain-containing protein 2; EF-hand calcium binding domain 2; Cilia and flagella associated	IQ domain-containing protein D; Cilia and flagella associated	0.762
EFCAB2	IQCG	ENSP00000355480	ENSP00000265239	EF-hand calcium-binding domain-containing protein 2; EF-hand calcium binding domain 2; Cilia and flagella associated	IQ domain-containing protein G; Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin- dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility	0.745
EFCAB2	TCTE1	ENSP00000355480	ENSP00000360560	EF-hand calcium-binding domain-containing protein 2; EF-hand calcium binding domain 2; Cilia and flagella associated	T-complex-associated-testis-expressed 1; Dynein regulatory complex	0.565
GAS8	CCDC135	ENSP00000268699	ENSP00000353942	Growth arrest-specific protein 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). May play a role in cilia motility; Dynein regulatory complex	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	0.719

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