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  • 11.0 [archived version]
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METTL21A METTL21A ZFAT ZFAT SBK3 SBK3 TSEN54 TSEN54 FAM86B1 FAM86B1 DEFB134 DEFB134 USP17L2 USP17L2 DEFB135 DEFB135 RPS23 RPS23 UTP18 UTP18 FAM167A FAM167A
"FAM86B1" - Putative protein N-methyltransferase FAM86B1 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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FAM86B1Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing (296 aa)    
Predicted Functional Partners:
DEFB134
Beta-defensin 134; Has antibacterial activity; Defensins, beta (66 aa)
           
  0.722
DEFB135
Beta-defensin 135; Has antibacterial activity; Defensins, beta (77 aa)
           
  0.703
SBK3
Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3 (359 aa)
           
  0.539
TSEN54
tRNA-splicing endonuclease subunit Sen54; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA bo [...] (526 aa)
           
  0.517
USP17L2
Ubiquitin carboxyl-terminal hydrolase 17; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetyl [...] (530 aa)
     
   
  0.483
ZFAT
Zinc finger protein ZFAT; May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity); Zinc fingers C2H2-type (1243 aa)
           
  0.476
METTL21A
Protein N-lysine methyltransferase METTL21A; Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates ’Lys-561’ in HSPA1, ’Lys- 564’ in HSPA2, ’Lys-585’ in HSPA5, ’Lys-563’ in HSPA6 and ’Lys- 561’ in HSPA8 (218 aa)
       
 
  0.473
FAM167A
Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family (214 aa)
           
  0.473
RPS23
40S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (143 aa)
     
 
  0.472
UTP18
U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA; UTPb subcomplex (556 aa)
     
      0.444
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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