node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DEFB134 | DEFB135 | ENSP00000435010 | ENSP00000371643 | Beta-defensin 134; Has antibacterial activity; Defensins, beta | Beta-defensin 135; Has antibacterial activity; Defensins, beta | 0.978 |
DEFB134 | FAM167A | ENSP00000435010 | ENSP00000284486 | Beta-defensin 134; Has antibacterial activity; Defensins, beta | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | 0.474 |
DEFB134 | FAM86B1 | ENSP00000435010 | ENSP00000407067 | Beta-defensin 134; Has antibacterial activity; Defensins, beta | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | 0.722 |
DEFB134 | USP17L2 | ENSP00000435010 | ENSP00000333329 | Beta-defensin 134; Has antibacterial activity; Defensins, beta | Ubiquitin carboxyl-terminal hydrolase 17; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetyl [...] | 0.426 |
DEFB135 | DEFB134 | ENSP00000371643 | ENSP00000435010 | Beta-defensin 135; Has antibacterial activity; Defensins, beta | Beta-defensin 134; Has antibacterial activity; Defensins, beta | 0.978 |
DEFB135 | FAM167A | ENSP00000371643 | ENSP00000284486 | Beta-defensin 135; Has antibacterial activity; Defensins, beta | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | 0.402 |
DEFB135 | FAM86B1 | ENSP00000371643 | ENSP00000407067 | Beta-defensin 135; Has antibacterial activity; Defensins, beta | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | 0.703 |
DEFB135 | USP17L2 | ENSP00000371643 | ENSP00000333329 | Beta-defensin 135; Has antibacterial activity; Defensins, beta | Ubiquitin carboxyl-terminal hydrolase 17; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetyl [...] | 0.400 |
FAM167A | DEFB134 | ENSP00000284486 | ENSP00000435010 | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | Beta-defensin 134; Has antibacterial activity; Defensins, beta | 0.474 |
FAM167A | DEFB135 | ENSP00000284486 | ENSP00000371643 | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | Beta-defensin 135; Has antibacterial activity; Defensins, beta | 0.402 |
FAM167A | FAM86B1 | ENSP00000284486 | ENSP00000407067 | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | 0.473 |
FAM86B1 | DEFB134 | ENSP00000407067 | ENSP00000435010 | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | Beta-defensin 134; Has antibacterial activity; Defensins, beta | 0.722 |
FAM86B1 | DEFB135 | ENSP00000407067 | ENSP00000371643 | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | Beta-defensin 135; Has antibacterial activity; Defensins, beta | 0.703 |
FAM86B1 | FAM167A | ENSP00000407067 | ENSP00000284486 | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family | 0.473 |
FAM86B1 | METTL21A | ENSP00000407067 | ENSP00000415115 | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | Protein N-lysine methyltransferase METTL21A; Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates ’Lys-561’ in HSPA1, ’Lys- 564’ in HSPA2, ’Lys-585’ in HSPA5, ’Lys-563’ in HSPA6 and ’Lys- 561’ in HSPA8 | 0.473 |
FAM86B1 | RPS23 | ENSP00000407067 | ENSP00000296674 | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | 40S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.472 |
FAM86B1 | SBK3 | ENSP00000407067 | ENSP00000483467 | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3 | 0.539 |
FAM86B1 | TSEN54 | ENSP00000407067 | ENSP00000327487 | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | tRNA-splicing endonuclease subunit Sen54; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA bo [...] | 0.517 |
FAM86B1 | USP17L2 | ENSP00000407067 | ENSP00000333329 | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | Ubiquitin carboxyl-terminal hydrolase 17; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetyl [...] | 0.483 |
FAM86B1 | UTP18 | ENSP00000407067 | ENSP00000225298 | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing | U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA; UTPb subcomplex | 0.444 |