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  • 11.0 [archived version]
STRINGSTRING
ZNF664 ZNF664 CST9L CST9L ENSG00000248592 ENSG00000248592 SPINK4 SPINK4 NEK4 NEK4 NT5DC2 NT5DC2 SLAIN1 SLAIN1 TMEM110 TMEM110 ASPHD1 ASPHD1 C2orf69 C2orf69 SAMD10 SAMD10
"NT5DC2" - 5'-nucleotidase domain containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
NT5DC25’-nucleotidase domain containing 2 (557 aa)    
Predicted Functional Partners:
ENSG00000248592
Store-operated calcium entry regulator STIMATE; Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store- dependent ER-PM junctions (372 aa)
            
  0.577
C2orf69
UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 (385 aa)
      
   
  0.571
TMEM110
TMEM110-MUSTN1 readthrough; Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store- dependent ER-PM junctions (294 aa)
            
  0.571
ZNF664
Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type (261 aa)
            
  0.557
SLAIN1
SLAIN motif-containing protein 1; Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation; Belongs to the SLAIN motif-containing family (590 aa)
            
  0.547
ASPHD1
Aspartate beta-hydroxylase domain containing 1 (390 aa)
            
  0.535
SPINK4
Serine peptidase inhibitor, Kazal type 4 (86 aa)
            
  0.534
SAMD10
Sterile alpha motif domain containing 10 (202 aa)
            
  0.523
NEK4
Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage (841 aa)
            
  0.514
CST9L
Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family (147 aa)
            
  0.510
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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