| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMBN | AMELX | ENSP00000313809 | ENSP00000370088 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | 0.995 |
| AMBN | AMTN | ENSP00000313809 | ENSP00000341013 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis | 0.987 |
| AMBN | C4orf26 | ENSP00000313809 | ENSP00000406925 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | 0.669 |
| AMBN | ENAM | ENSP00000313809 | ENSP00000379383 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.992 |
| AMBN | FAM20A | ENSP00000313809 | ENSP00000468308 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the ’matrix’ that guides the deposition of the enamel minerals | 0.972 |
| AMBN | FAM83H | ENSP00000313809 | ENSP00000373565 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration | 0.723 |
| AMBN | MMP20 | ENSP00000313809 | ENSP00000260228 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the ’360-Asn-|-Phe-361’ site; M10 matrix metallopeptidases | 0.897 |
| AMBN | MMP25 | ENSP00000313809 | ENSP00000337816 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Matrix metalloproteinase-25; May activate progelatinase A; M10 matrix metallopeptidases | 0.726 |
| AMBN | SLC24A4 | ENSP00000313809 | ENSP00000431840 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity); Belongs to the Ca(2+)-cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily | 0.552 |
| AMBN | WDR72 | ENSP00000313809 | ENSP00000379619 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane; WD repeat domain containing | 0.724 |
| AMELX | AMBN | ENSP00000370088 | ENSP00000313809 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | 0.995 |
| AMELX | AMTN | ENSP00000370088 | ENSP00000341013 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis | 0.982 |
| AMELX | C4orf26 | ENSP00000370088 | ENSP00000406925 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | 0.669 |
| AMELX | ENAM | ENSP00000370088 | ENSP00000379383 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.995 |
| AMELX | FAM20A | ENSP00000370088 | ENSP00000468308 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the ’matrix’ that guides the deposition of the enamel minerals | 0.963 |
| AMELX | FAM83H | ENSP00000370088 | ENSP00000373565 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration | 0.790 |
| AMELX | MMP20 | ENSP00000370088 | ENSP00000260228 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the ’360-Asn-|-Phe-361’ site; M10 matrix metallopeptidases | 0.921 |
| AMELX | MMP25 | ENSP00000370088 | ENSP00000337816 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Matrix metalloproteinase-25; May activate progelatinase A; M10 matrix metallopeptidases | 0.730 |
| AMELX | SLC24A4 | ENSP00000370088 | ENSP00000431840 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity); Belongs to the Ca(2+)-cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily | 0.518 |
| AMELX | WDR72 | ENSP00000370088 | ENSP00000379619 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane; WD repeat domain containing | 0.760 |
