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  • 11.0 [archived version]
STRINGSTRING
CLN3 CLN3 TMA16 TMA16 ENSG00000261832 ENSG00000261832 TUFM TUFM C4orf27 C4orf27 APLF APLF PARP1 PARP1 PARG PARG PARP2 PARP2 C14orf1 C14orf1 C14orf2 C14orf2
"C4orf27" - Histone PARylation factor 1 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
C4orf27Histone PARylation factor 1; Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2- interacts with PARP1 and PARP1 and is able to change amino acid specificity toward serine. Promotes histone serine ADP- ribosylation in response to DNA damage, limiting DNA damage- induced PARP1 hyper-automodification, and ensuring genome stability (346 aa)    
Predicted Functional Partners:
PARP2
Poly [ADP-ribose] polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity; Poly(ADP-ribose) polymerases (583 aa)
     
 
  0.728
PARP1
Poly [ADP-ribose] polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T [...] (1014 aa)
     
 
  0.645
TUFM
Elongation factor Tu, mitochondrial; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily (455 aa)
           
  0.620
PARG
Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP- ribose monomers. Required for retinoid acid- dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR- dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for exten [...] (976 aa)
     
   
  0.558
TMA16
Translation machinery associated 16 homolog (203 aa)
     
   
  0.551
APLF
Aprataxin and PNK-like factor; Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3’-5’ exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage; Zinc fingers (511 aa)
     
 
  0.547
ENSG00000261832
Battenin isoform d (360 aa)
     
   
  0.529
CLN3
Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes (438 aa)
     
   
  0.529
C14orf1
Probable ergosterol biosynthetic protein 28; Chromosome 14 open reading frame 1; Belongs to the ERG28 family (140 aa)
           
  0.502
C14orf2
6.8 kDa mitochondrial proteolipid; Chromosome 14 open reading frame 2 (75 aa)
           
  0.493
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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