| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AR | ETV1 | ENSP00000363822 | ENSP00000405327 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | 0.750 |
| AR | MAPK14 | ENSP00000363822 | ENSP00000229795 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.945 |
| AR | PAX6 | ENSP00000363822 | ENSP00000404100 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes; Belongs to the paired homeobox family | 0.669 |
| AR | TMPRSS2 | ENSP00000363822 | ENSP00000381588 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | Transmembrane protease serine 2; Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which ac [...] | 0.940 |
| DET1 | ETV1 | ENSP00000456340 | ENSP00000405327 | DET1 homolog; Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | 0.874 |
| DET1 | RFWD2 | ENSP00000456340 | ENSP00000356641 | DET1 homolog; Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | E3 ubiquitin-protein ligase RFWD2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activit [...] | 0.979 |
| DET1 | STK40 | ENSP00000456340 | ENSP00000362222 | DET1 homolog; Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53- mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family | 0.817 |
| ETV1 | AR | ENSP00000405327 | ENSP00000363822 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.750 |
| ETV1 | DET1 | ENSP00000405327 | ENSP00000456340 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | DET1 homolog; Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation | 0.874 |
| ETV1 | EWSR1 | ENSP00000405327 | ENSP00000400142 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | RNA-binding protein EWS; Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes; Belongs to the RRM TET family | 0.700 |
| ETV1 | MAPK11 | ENSP00000405327 | ENSP00000333685 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | Mitogen-activated protein kinase 11; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MA [...] | 0.913 |
| ETV1 | MAPK14 | ENSP00000405327 | ENSP00000229795 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.940 |
| ETV1 | MAPKAPK2 | ENSP00000405327 | ENSP00000356070 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...] | 0.959 |
| ETV1 | PAX6 | ENSP00000405327 | ENSP00000404100 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes; Belongs to the paired homeobox family | 0.796 |
| ETV1 | RFWD2 | ENSP00000405327 | ENSP00000356641 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | E3 ubiquitin-protein ligase RFWD2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activit [...] | 0.896 |
| ETV1 | STK40 | ENSP00000405327 | ENSP00000362222 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53- mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family | 0.859 |
| ETV1 | TMPRSS2 | ENSP00000405327 | ENSP00000381588 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | Transmembrane protease serine 2; Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which ac [...] | 0.803 |
| EWSR1 | ETV1 | ENSP00000400142 | ENSP00000405327 | RNA-binding protein EWS; Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes; Belongs to the RRM TET family | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | 0.700 |
| EWSR1 | TMPRSS2 | ENSP00000400142 | ENSP00000381588 | RNA-binding protein EWS; Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes; Belongs to the RRM TET family | Transmembrane protease serine 2; Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which ac [...] | 0.518 |
| MAPK11 | ETV1 | ENSP00000333685 | ENSP00000405327 | Mitogen-activated protein kinase 11; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MA [...] | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; Belongs to the ETS family | 0.913 |
