node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACHE | ZNF347 | ENSP00000303211 | ENSP00000405218 | Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis; Belongs to the type-B carboxylesterase/lipase family | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.473 |
EMC3 | ZNF347 | ENSP00000245046 | ENSP00000405218 | ER membrane protein complex subunit 3 | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.518 |
EN1 | KDM4A | ENSP00000295206 | ENSP00000361473 | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively; Lysi [...] | 0.410 |
EN1 | PNMT | ENSP00000295206 | ENSP00000269582 | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family | 0.746 |
EN1 | ZNF347 | ENSP00000295206 | ENSP00000405218 | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.581 |
EN2 | PNMT | ENSP00000297375 | ENSP00000269582 | Homeobox protein engrailed-2; NKL subclass homeoboxes and pseudogenes; Belongs to the engrailed homeobox family | Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family | 0.753 |
EN2 | ZNF347 | ENSP00000297375 | ENSP00000405218 | Homeobox protein engrailed-2; NKL subclass homeoboxes and pseudogenes; Belongs to the engrailed homeobox family | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.648 |
EXO5 | ZNF347 | ENSP00000361788 | ENSP00000405218 | Exonuclease V; Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5’-3’ and 3’-5’ exonuclease activities with a strong preference for 5’-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3’-5’ exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5’-directionality activity; Exonucleases | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.565 |
KDM4A | EN1 | ENSP00000361473 | ENSP00000295206 | Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively; Lysi [...] | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | 0.410 |
KDM4A | PNMT | ENSP00000361473 | ENSP00000269582 | Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively; Lysi [...] | Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family | 0.444 |
KDM4A | ZNF347 | ENSP00000361473 | ENSP00000405218 | Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively; Lysi [...] | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.582 |
PHIP | ZNF347 | ENSP00000275034 | ENSP00000405218 | PH-interacting protein; Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti- apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization; Bromodomain containing | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.654 |
PNMT | EN1 | ENSP00000269582 | ENSP00000295206 | Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | 0.746 |
PNMT | EN2 | ENSP00000269582 | ENSP00000297375 | Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family | Homeobox protein engrailed-2; NKL subclass homeoboxes and pseudogenes; Belongs to the engrailed homeobox family | 0.753 |
PNMT | KDM4A | ENSP00000269582 | ENSP00000361473 | Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family | Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively; Lysi [...] | 0.444 |
PNMT | ZNF347 | ENSP00000269582 | ENSP00000405218 | Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.831 |
SLC38A5 | ZNF347 | ENSP00000471683 | ENSP00000405218 | Sodium-coupled neutral amino acid transporter 5; Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH- sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.448 |
TRIM28 | ZNF347 | ENSP00000253024 | ENSP00000405218 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.908 |
ZNF347 | ACHE | ENSP00000405218 | ENSP00000303211 | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis; Belongs to the type-B carboxylesterase/lipase family | 0.473 |
ZNF347 | EMC3 | ENSP00000405218 | ENSP00000245046 | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type | ER membrane protein complex subunit 3 | 0.518 |