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  • 11.0 [archived version]
STRINGSTRING
SLC38A5 SLC38A5 EXO5 EXO5 ACHE ACHE TRIM28 TRIM28 PHIP PHIP ZNF347 ZNF347 EMC3 EMC3 EN2 EN2 EN1 EN1 PNMT PNMT KDM4A KDM4A
"ZNF347" - Zinc finger protein 347 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF347Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type (840 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.908
PNMT
Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family (282 aa)
           
  0.831
PHIP
PH-interacting protein; Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti- apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization; Bromodomain containing (1821 aa)
     
 
  0.654
EN2
Homeobox protein engrailed-2; NKL subclass homeoboxes and pseudogenes; Belongs to the engrailed homeobox family (333 aa)
       
 
  0.648
KDM4A
Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively; Lysi [...] (1064 aa)
     
 
  0.582
EN1
Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes (392 aa)
       
 
  0.581
EXO5
Exonuclease V; Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5’-3’ and 3’-5’ exonuclease activities with a strong preference for 5’-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3’-5’ exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5’-directionality activity; Exonucleases (373 aa)
     
   
  0.565
EMC3
ER membrane protein complex subunit 3 (261 aa)
           
  0.518
ACHE
Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis; Belongs to the type-B carboxylesterase/lipase family (617 aa)
           
  0.473
SLC38A5
Sodium-coupled neutral amino acid transporter 5; Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH- sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium (472 aa)
           
  0.448
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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