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  • 11.0 [archived version]
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PPID PPID ARFIP2 ARFIP2 NRN1 NRN1 FRRS1L FRRS1L VWC2 VWC2 GSG1 GSG1 SHISA9 SHISA9 C10orf62 C10orf62 FHL5 FHL5 ATP4A ATP4A TMEM39B TMEM39B
"GSG1" - Germ cell-specific gene 1 protein in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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GSG1Germ cell-specific gene 1 protein; May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum (339 aa)    
Predicted Functional Partners:
ATP4A
Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; ATPase H+/K+ transporting (1035 aa)
     
   
  0.652
SHISA9
Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity); Belongs to the shisa family. SHISA9 subfamily (424 aa)
     
   
  0.536
ARFIP2
Arfaptin-2; Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling; Classical BAR domain containing (374 aa)
       
      0.536
FHL5
Four and a half LIM domains protein 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner; LIM domain containing (284 aa)
     
   
  0.515
NRN1
Neuritin; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (168 aa)
           
  0.514
PPID
Peptidyl-prolyl cis-trans isomerase D; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexe [...] (370 aa)
           
  0.493
C10orf62
Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62 (223 aa)
     
   
  0.488
VWC2
Brorin; BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity) (325 aa)
           
  0.483
TMEM39B
Transmembrane protein 39B; Belongs to the TMEM39 family (492 aa)
           
  0.473
FRRS1L
DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway (344 aa)
     
   
  0.455
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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