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  • 11.0 [archived version]
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ARHGAP27 ARHGAP27 PCDHB3 PCDHB3 RAB40A RAB40A FRS3 FRS3 C6orf49 C6orf49 VANGL1 VANGL1 USP49 USP49 DVL2 DVL2 DVL3 DVL3 DVL1 DVL1 VANGL2 VANGL2
"C6orf49" - Prickle planar cell polarity protein 4 in Homo sapiens
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Predicted Interactions
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textmining
co-expression
protein homology
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C6orf49Prickle planar cell polarity protein 4; Belongs to the prickle / espinas / testin family (384 aa)    
Predicted Functional Partners:
VANGL1
VANGL planar cell polarity protein 1 (524 aa)
     
  0.894
VANGL2
Vang-like protein 2; Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity) (521 aa)
     
  0.882
DVL2
Segment polarity protein dishevelled homolog DVL-2; Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C- terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling; Belongs to the DSH family (736 aa)
     
  0.772
DVL3
Segment polarity protein dishevelled homolog DVL-3; May play a role in the signal transduction pathway mediated by multiple Wnt genes; Dishevelled segment polarity proteins (716 aa)
     
  0.759
DVL1
Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ); Disheve [...] (670 aa)
     
  0.754
USP49
Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at ’Lys-120’ (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family (688 aa)
     
   
  0.578
FRS3
Fibroblast growth factor receptor substrate 3; Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2 (492 aa)
     
   
  0.566
ARHGAP27
Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing (889 aa)
     
 
  0.479
PCDHB3
Protocadherin beta-3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (796 aa)
       
 
  0.454
RAB40A
Ras-related protein Rab-40A; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the small GTPase superfamily. Rab family (277 aa)
           
  0.441
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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