EFHC2 protein (human) - STRING database

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EFHC2

EF-hand domain-containing family member C2; EF-hand domain containing 2 (749 aa)

Predicted Functional Partners:

GPR82

0.834

GPR34

0.805

ARHGEF5

0.727

CXorf23

0.727

GRAMD2

0.689

CRYZL1

0.647

GTF2IRD1

0.640

FUNDC1

0.618

PRODH2

0.608

RFC2

0.598

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF5	EFHC2	ENSP00000056217	ENSP00000404232	Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...]	EF-hand domain-containing family member C2; EF-hand domain containing 2	0.727
CRYZL1	EFHC2	ENSP00000370966	ENSP00000404232	Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	EF-hand domain-containing family member C2; EF-hand domain containing 2	0.647
CRYZL1	GPR34	ENSP00000370966	ENSP00000367384	Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	Probable G-protein coupled receptor 34; Orphan receptor; G protein-coupled receptors, Class A orphans	0.573
CXorf23	EFHC2	ENSP00000369009	ENSP00000404232	BCLAF1 and THRAP3 family member 3; Chromosome X open reading frame 23; Belongs to the BCLAF1/THRAP3 family	EF-hand domain-containing family member C2; EF-hand domain containing 2	0.727
EFHC2	ARHGEF5	ENSP00000404232	ENSP00000056217	EF-hand domain-containing family member C2; EF-hand domain containing 2	Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...]	0.727
EFHC2	CRYZL1	ENSP00000404232	ENSP00000370966	EF-hand domain-containing family member C2; EF-hand domain containing 2	Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	0.647
EFHC2	CXorf23	ENSP00000404232	ENSP00000369009	EF-hand domain-containing family member C2; EF-hand domain containing 2	BCLAF1 and THRAP3 family member 3; Chromosome X open reading frame 23; Belongs to the BCLAF1/THRAP3 family	0.727
EFHC2	FUNDC1	ENSP00000404232	ENSP00000367284	EF-hand domain-containing family member C2; EF-hand domain containing 2	FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	0.618
EFHC2	GPR34	ENSP00000404232	ENSP00000367384	EF-hand domain-containing family member C2; EF-hand domain containing 2	Probable G-protein coupled receptor 34; Orphan receptor; G protein-coupled receptors, Class A orphans	0.805
EFHC2	GPR82	ENSP00000404232	ENSP00000303549	EF-hand domain-containing family member C2; EF-hand domain containing 2	Probable G-protein coupled receptor 82; Orphan receptor; G protein-coupled receptors, Class A orphans	0.834
EFHC2	GRAMD2	ENSP00000404232	ENSP00000311657	EF-hand domain-containing family member C2; EF-hand domain containing 2	GRAM domain-containing protein 2A; GRAM domain containing 2	0.689
EFHC2	GTF2IRD1	ENSP00000404232	ENSP00000397566	EF-hand domain-containing family member C2; EF-hand domain containing 2	General transcription factor II-I repeat domain-containing protein 1; May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity)	0.640
EFHC2	PRODH2	ENSP00000404232	ENSP00000301175	EF-hand domain-containing family member C2; EF-hand domain containing 2	Hydroxyproline dehydrogenase; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone- 10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp- trans-4-D-hydroxyproline and cis- 4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis	0.608
EFHC2	RFC2	ENSP00000404232	ENSP00000055077	EF-hand domain-containing family member C2; EF-hand domain containing 2	Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity)	0.598
FUNDC1	EFHC2	ENSP00000367284	ENSP00000404232	FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	EF-hand domain-containing family member C2; EF-hand domain containing 2	0.618
FUNDC1	GRAMD2	ENSP00000367284	ENSP00000311657	FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	GRAM domain-containing protein 2A; GRAM domain containing 2	0.533
GPR34	CRYZL1	ENSP00000367384	ENSP00000370966	Probable G-protein coupled receptor 34; Orphan receptor; G protein-coupled receptors, Class A orphans	Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	0.573
GPR34	EFHC2	ENSP00000367384	ENSP00000404232	Probable G-protein coupled receptor 34; Orphan receptor; G protein-coupled receptors, Class A orphans	EF-hand domain-containing family member C2; EF-hand domain containing 2	0.805
GPR82	EFHC2	ENSP00000303549	ENSP00000404232	Probable G-protein coupled receptor 82; Orphan receptor; G protein-coupled receptors, Class A orphans	EF-hand domain-containing family member C2; EF-hand domain containing 2	0.834
GRAMD2	EFHC2	ENSP00000311657	ENSP00000404232	GRAM domain-containing protein 2A; GRAM domain containing 2	EF-hand domain-containing family member C2; EF-hand domain containing 2	0.689

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