CEP170B protein (human) - STRING database

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CEP170B

Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization (1554 aa)

Predicted Functional Partners:

GGT5

0.711

KIF2B

0.689

C6orf201

0.645

PAPSS1

0.590

CEP170

0.570

DYNLL1

0.558

ULK2

0.531

LRP5L

0.530

CCDC73

0.530

CLGN

0.529

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C6orf201	CCDC73	ENSP00000420610	ENSP00000335325	Uncharacterized protein C6orf201; Chromosome 6 open reading frame 201	Coiled-coil domain containing 73	0.669
C6orf201	CEP170B	ENSP00000420610	ENSP00000404151	Uncharacterized protein C6orf201; Chromosome 6 open reading frame 201	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	0.645
CCDC73	C6orf201	ENSP00000335325	ENSP00000420610	Coiled-coil domain containing 73	Uncharacterized protein C6orf201; Chromosome 6 open reading frame 201	0.669
CCDC73	CEP170B	ENSP00000335325	ENSP00000404151	Coiled-coil domain containing 73	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	0.530
CEP170	CEP170B	ENSP00000355500	ENSP00000404151	Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	0.570
CEP170	KIF2B	ENSP00000355500	ENSP00000268919	Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family	Kinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression; Kinesins	0.700
CEP170B	C6orf201	ENSP00000404151	ENSP00000420610	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	Uncharacterized protein C6orf201; Chromosome 6 open reading frame 201	0.645
CEP170B	CCDC73	ENSP00000404151	ENSP00000335325	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	Coiled-coil domain containing 73	0.530
CEP170B	CEP170	ENSP00000404151	ENSP00000355500	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family	0.570
CEP170B	CLGN	ENSP00000404151	ENSP00000326699	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity)	0.529
CEP170B	DYNLL1	ENSP00000404151	ENSP00000376297	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures; Belongs to the dynein light chain family	0.558
CEP170B	GGT5	ENSP00000404151	ENSP00000381340	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family	0.711
CEP170B	KIF2B	ENSP00000404151	ENSP00000268919	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	Kinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression; Kinesins	0.689
CEP170B	LRP5L	ENSP00000404151	ENSP00000482378	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	Low-density lipoprotein receptor-related protein 5-like protein; LDL receptor related protein 5 like	0.530
CEP170B	PAPSS1	ENSP00000404151	ENSP00000265174	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Required [...]	0.590
CEP170B	ULK2	ENSP00000404151	ENSP00000378914	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG [...]	0.531
CLGN	CEP170B	ENSP00000326699	ENSP00000404151	Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity)	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	0.529
DYNLL1	CEP170B	ENSP00000376297	ENSP00000404151	Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures; Belongs to the dynein light chain family	Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization	0.558
DYNLL1	GGT5	ENSP00000376297	ENSP00000381340	Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures; Belongs to the dynein light chain family	Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family	0.453
DYNLL1	KIF2B	ENSP00000376297	ENSP00000268919	Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures; Belongs to the dynein light chain family	Kinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression; Kinesins	0.910

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