node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAGE5 | GAGE12F | ENSP00000485185 | ENSP00000404123 | B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family | G antigen 12F; Belongs to the GAGE family | 0.905 |
BAGE5 | GAGE13 | ENSP00000485185 | ENSP00000483811 | B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family | G antigen 13 | 0.721 |
BAGE5 | GAGE2A | ENSP00000485185 | ENSP00000355421 | B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family | G antigen 2A | 0.906 |
BAGE5 | MAGEA1 | ENSP00000485185 | ENSP00000349085 | B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | 0.905 |
BAGE5 | MAGEA12 | ENSP00000485185 | ENSP00000377478 | B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family | Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines; MAGE family | 0.581 |
BAGE5 | MAGEA2 | ENSP00000485185 | ENSP00000485541 | B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family | Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal d [...] | 0.590 |
BAGE5 | MAGEA2B | ENSP00000485185 | ENSP00000333487 | B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family | Melanoma antigen family A, 2B; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal d [...] | 0.590 |
BAGE5 | MAGEA3 | ENSP00000485185 | ENSP00000473093 | B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MA [...] | 0.882 |
GAGE12F | BAGE5 | ENSP00000404123 | ENSP00000485185 | G antigen 12F; Belongs to the GAGE family | B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family | 0.905 |
GAGE12F | GAGE12G | ENSP00000404123 | ENSP00000416249 | G antigen 12F; Belongs to the GAGE family | G antigen 12G; Belongs to the GAGE family | 0.771 |
GAGE12F | GAGE13 | ENSP00000404123 | ENSP00000483811 | G antigen 12F; Belongs to the GAGE family | G antigen 13 | 0.727 |
GAGE12F | GAGE2A | ENSP00000404123 | ENSP00000355421 | G antigen 12F; Belongs to the GAGE family | G antigen 2A | 0.774 |
GAGE12F | GMCL1 | ENSP00000404123 | ENSP00000282570 | G antigen 12F; Belongs to the GAGE family | Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity); BTB domain containing | 0.743 |
GAGE12F | MAGEA1 | ENSP00000404123 | ENSP00000349085 | G antigen 12F; Belongs to the GAGE family | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | 0.889 |
GAGE12F | MAGEA12 | ENSP00000404123 | ENSP00000377478 | G antigen 12F; Belongs to the GAGE family | Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines; MAGE family | 0.701 |
GAGE12F | MAGEA2 | ENSP00000404123 | ENSP00000485541 | G antigen 12F; Belongs to the GAGE family | Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal d [...] | 0.667 |
GAGE12F | MAGEA2B | ENSP00000404123 | ENSP00000333487 | G antigen 12F; Belongs to the GAGE family | Melanoma antigen family A, 2B; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal d [...] | 0.655 |
GAGE12F | MAGEA3 | ENSP00000404123 | ENSP00000473093 | G antigen 12F; Belongs to the GAGE family | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MA [...] | 0.890 |
GAGE12G | GAGE12F | ENSP00000416249 | ENSP00000404123 | G antigen 12G; Belongs to the GAGE family | G antigen 12F; Belongs to the GAGE family | 0.771 |
GAGE12G | GAGE13 | ENSP00000416249 | ENSP00000483811 | G antigen 12G; Belongs to the GAGE family | G antigen 13 | 0.752 |