C11orf74 protein (human) - STRING database

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C11orf74

Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74 (221 aa)

Predicted Functional Partners:

IFT43

0.896

WDR19

0.895

IFT122

0.884

WDR35

0.863

IFT140

0.860

ZNF397

0.607

RNH1

0.554

DUPD1

0.550

RAG2

0.518

C14orf119

0.517

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C11orf74	C14orf119	ENSP00000403937	ENSP00000322238	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	Uncharacterized protein C14orf119; Chromosome 14 open reading frame 119	0.517
C11orf74	DUPD1	ENSP00000403937	ENSP00000340609	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate	0.550
C11orf74	IFT122	ENSP00000403937	ENSP00000296266	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	Intraflagellar transport protein 122 homolog; Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity); Intraflagellar transport proteins	0.884
C11orf74	IFT140	ENSP00000403937	ENSP00000406012	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance. May play a role in ciliary assembly. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity); Intraflagellar transport proteins	0.860
C11orf74	IFT43	ENSP00000403937	ENSP00000238628	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	Intraflagellar transport proteins	0.896
C11orf74	RAG2	ENSP00000403937	ENSP00000478672	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps- a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3’-hydroxyl group that can attack the pho [...]	0.518
C11orf74	RNH1	ENSP00000403937	ENSP00000433999	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	Ribonuclease inhibitor; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis	0.554
C11orf74	WDR19	ENSP00000403937	ENSP00000382717	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	WD repeat-containing protein 19; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in cilia function and/or assembly (By similarity). Associates with the BBSome complex to mediate ciliary transport (By similarity); Intraflagellar transport proteins	0.895
C11orf74	WDR35	ENSP00000403937	ENSP00000314444	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	WD repeat-containing protein 35; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis; Intraflagellar transport proteins	0.863
C11orf74	ZNF397	ENSP00000403937	ENSP00000331577	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	Zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor; SCAN domain containing	0.607
C14orf119	C11orf74	ENSP00000322238	ENSP00000403937	Uncharacterized protein C14orf119; Chromosome 14 open reading frame 119	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	0.517
C14orf119	DUPD1	ENSP00000322238	ENSP00000340609	Uncharacterized protein C14orf119; Chromosome 14 open reading frame 119	Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate	0.494
C14orf119	ZNF397	ENSP00000322238	ENSP00000331577	Uncharacterized protein C14orf119; Chromosome 14 open reading frame 119	Zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor; SCAN domain containing	0.547
DUPD1	C11orf74	ENSP00000340609	ENSP00000403937	Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	0.550
DUPD1	C14orf119	ENSP00000340609	ENSP00000322238	Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate	Uncharacterized protein C14orf119; Chromosome 14 open reading frame 119	0.494
DUPD1	ZNF397	ENSP00000340609	ENSP00000331577	Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate	Zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor; SCAN domain containing	0.580
IFT122	C11orf74	ENSP00000296266	ENSP00000403937	Intraflagellar transport protein 122 homolog; Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity); Intraflagellar transport proteins	Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74	0.884
IFT122	IFT140	ENSP00000296266	ENSP00000406012	Intraflagellar transport protein 122 homolog; Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity); Intraflagellar transport proteins	Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance. May play a role in ciliary assembly. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity); Intraflagellar transport proteins	0.999
IFT122	IFT43	ENSP00000296266	ENSP00000238628	Intraflagellar transport protein 122 homolog; Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity); Intraflagellar transport proteins	Intraflagellar transport proteins	0.997
IFT122	WDR19	ENSP00000296266	ENSP00000382717	Intraflagellar transport protein 122 homolog; Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity); Intraflagellar transport proteins	WD repeat-containing protein 19; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in cilia function and/or assembly (By similarity). Associates with the BBSome complex to mediate ciliary transport (By similarity); Intraflagellar transport proteins	0.993

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