• Version:
  • 11.0 [archived version]
STRINGSTRING
OBSCN OBSCN MYH10 MYH10 EFCAB13 EFCAB13 SPEG SPEG PGBD5 PGBD5 EFCAB3 EFCAB3 PAQR8 PAQR8 ZNF395 ZNF395 MARCH10 MARCH10 IQCF2 IQCF2 METTL2A METTL2A
"EFCAB3" - EF-hand calcium-binding domain-containing protein 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EFCAB3EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3 (490 aa)    
Predicted Functional Partners:
IQCF2
IQ motif containing F2 (164 aa)
           
  0.812
MYH10
Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (2007 aa)
       
 
  0.634
OBSCN
Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; Fibronectin type III domain containing (8923 aa)
       
 
  0.601
SPEG
Striated muscle preferentially expressed protein kinase; Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells; I-set domain containing (3267 aa)
       
 
  0.601
EFCAB13
EF-hand calcium-binding domain-containing protein 13; EF-hand calcium binding domain 13 (973 aa)
 
            0.601
METTL2A
Methyltransferase-like protein 2A; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs (378 aa)
           
  0.558
MARCH10
Probable E3 ubiquitin-protein ligase MARCH10; E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers (846 aa)
     
   
  0.547
PAQR8
Membrane progestin receptor beta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone; Belongs to the ADIPOR family (354 aa)
           
  0.537
PGBD5
PiggyBac transposable element-derived protein 5; Transposase that mediates sequence-specific genomic rearrangements. Can induce genomic rearrangements that inactivate the HPRT1 gene; DNA transposon derived genes (455 aa)
           
  0.535
ZNF395
Zinc finger protein 395; Plays a role in papillomavirus genes transcription; Zinc fingers C2H2-type (513 aa)
           
  0.517
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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