TBCEL protein (human) - STRING database

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TBCEL

Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability (424 aa)

Predicted Functional Partners:

TBCD

0.912

TBCC

0.905

TECTA

0.900

TBCB

0.732

MITD1

0.715

ATAT1

0.600

RASA2

0.594

GKAP1

0.588

RHPN2

0.588

KIF27

0.583

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAT1	TBCEL	ENSP00000327832	ENSP00000403925	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates ’Lys-40’ in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.600
GKAP1	KIF27	ENSP00000365550	ENSP00000297814	G kinase anchoring protein 1; Belongs to the GKAP1 family	Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins	0.583
GKAP1	TBCEL	ENSP00000365550	ENSP00000403925	G kinase anchoring protein 1; Belongs to the GKAP1 family	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.588
KIF27	GKAP1	ENSP00000297814	ENSP00000365550	Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins	G kinase anchoring protein 1; Belongs to the GKAP1 family	0.583
KIF27	TBCEL	ENSP00000297814	ENSP00000403925	Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.583
MITD1	TBCEL	ENSP00000289359	ENSP00000403925	MIT domain-containing protein 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.715
RASA2	RHPN2	ENSP00000286364	ENSP00000254260	Ras GTPase-activating protein 2; Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4); C2 and RasGAP domain containing	Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity; Belongs to the RHPN family	0.576
RASA2	TBCEL	ENSP00000286364	ENSP00000403925	Ras GTPase-activating protein 2; Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4); C2 and RasGAP domain containing	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.594
RHPN2	RASA2	ENSP00000254260	ENSP00000286364	Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity; Belongs to the RHPN family	Ras GTPase-activating protein 2; Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4); C2 and RasGAP domain containing	0.576
RHPN2	TBCEL	ENSP00000254260	ENSP00000403925	Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity; Belongs to the RHPN family	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.588
TBCB	TBCC	ENSP00000221855	ENSP00000361967	Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity); Belongs to the TBCB family	Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family	0.900
TBCB	TBCD	ENSP00000221855	ENSP00000347719	Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity); Belongs to the TBCB family	Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epi [...]	0.992
TBCB	TBCEL	ENSP00000221855	ENSP00000403925	Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity); Belongs to the TBCB family	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.732
TBCC	TBCB	ENSP00000361967	ENSP00000221855	Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family	Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity); Belongs to the TBCB family	0.900
TBCC	TBCD	ENSP00000361967	ENSP00000347719	Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family	Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epi [...]	0.992
TBCC	TBCEL	ENSP00000361967	ENSP00000403925	Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.905
TBCD	TBCB	ENSP00000347719	ENSP00000221855	Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epi [...]	Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity); Belongs to the TBCB family	0.992
TBCD	TBCC	ENSP00000347719	ENSP00000361967	Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epi [...]	Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family	0.992
TBCD	TBCEL	ENSP00000347719	ENSP00000403925	Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epi [...]	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.912
TBCEL	ATAT1	ENSP00000403925	ENSP00000327832	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates ’Lys-40’ in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]	0.600

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