node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DGCR2 | MRPL40 | ENSP00000263196 | ENSP00000333401 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | 0.530 |
DGCR2 | TANGO2 | ENSP00000263196 | ENSP00000403645 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | Transport and golgi organization 2 homolog | 0.577 |
DGCR2 | TRMT2A | ENSP00000263196 | ENSP00000252136 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | tRNA (uracil-5-)-methyltransferase homolog A; May be involved in nucleic acid metabolism and/or modifications; tRNA methyltransferases | 0.619 |
DGCR2 | UFD1L | ENSP00000263196 | ENSP00000263202 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derive [...] | 0.621 |
DGCR2 | ZDHHC8 | ENSP00000263196 | ENSP00000384716 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily | 0.679 |
EMC1 | KATNB1 | ENSP00000420608 | ENSP00000368982 | ER membrane protein complex subunit 1; Belongs to the EMC1 family | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] | 0.570 |
EMC1 | TANGO2 | ENSP00000420608 | ENSP00000403645 | ER membrane protein complex subunit 1; Belongs to the EMC1 family | Transport and golgi organization 2 homolog | 0.648 |
KATNB1 | EMC1 | ENSP00000368982 | ENSP00000420608 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] | ER membrane protein complex subunit 1; Belongs to the EMC1 family | 0.570 |
KATNB1 | TANGO2 | ENSP00000368982 | ENSP00000403645 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] | Transport and golgi organization 2 homolog | 0.607 |
MRPL40 | DGCR2 | ENSP00000333401 | ENSP00000263196 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | 0.530 |
MRPL40 | TANGO2 | ENSP00000333401 | ENSP00000403645 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | Transport and golgi organization 2 homolog | 0.785 |
MRPL40 | TRMT2A | ENSP00000333401 | ENSP00000252136 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | tRNA (uracil-5-)-methyltransferase homolog A; May be involved in nucleic acid metabolism and/or modifications; tRNA methyltransferases | 0.654 |
MRPL40 | UFD1L | ENSP00000333401 | ENSP00000263202 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derive [...] | 0.730 |
MRPL40 | ZDHHC8 | ENSP00000333401 | ENSP00000384716 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily | 0.715 |
NUS1 | TANGO2 | ENSP00000357480 | ENSP00000403645 | Dehydrodolichyl diphosphate synthase complex subunit NUS1; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholestero [...] | Transport and golgi organization 2 homolog | 0.646 |
PRDX1 | TANGO2 | ENSP00000262746 | ENSP00000403645 | Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By s [...] | Transport and golgi organization 2 homolog | 0.818 |
SH3GL2 | TANGO2 | ENSP00000369981 | ENSP00000403645 | Endophilin-A1; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes; N-BAR domain containing | Transport and golgi organization 2 homolog | 0.689 |
TANGO2 | DGCR2 | ENSP00000403645 | ENSP00000263196 | Transport and golgi organization 2 homolog | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lectin domain containing | 0.577 |
TANGO2 | EMC1 | ENSP00000403645 | ENSP00000420608 | Transport and golgi organization 2 homolog | ER membrane protein complex subunit 1; Belongs to the EMC1 family | 0.648 |
TANGO2 | KATNB1 | ENSP00000403645 | ENSP00000368982 | Transport and golgi organization 2 homolog | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] | 0.607 |