node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNA2D1 | PHTF2 | ENSP00000349320 | ENSP00000403042 | Voltage-dependent calcium channel subunit alpha-2/delta-1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) | Putative homeodomain transcription factor 2; May play a role in transcription regulation | 0.491 |
FAM114A1 | PHTF2 | ENSP00000351740 | ENSP00000403042 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Putative homeodomain transcription factor 2; May play a role in transcription regulation | 0.473 |
FAM114A1 | ZNF518B | ENSP00000351740 | ENSP00000317614 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.490 |
FIGN | PHTF2 | ENSP00000333836 | ENSP00000403042 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | Putative homeodomain transcription factor 2; May play a role in transcription regulation | 0.558 |
FIGN | SHPRH | ENSP00000333836 | ENSP00000356475 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to ’Lys-164’ of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through ’Lys-63’; Belongs to the SNF2/RAD54 helicase family | 0.575 |
FIGN | SMARCAD1 | ENSP00000333836 | ENSP00000351947 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | ATP-dependent helicase 1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage- probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 ’Lys-9’ trimethylation (H3K9me3) and restorati [...] | 0.484 |
FIGN | SRSF7 | ENSP00000333836 | ENSP00000325905 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | Serine/arginine-rich splicing factor 7; Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific | 0.511 |
FIGN | TTLL4 | ENSP00000333836 | ENSP00000375951 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | Tubulin polyglutamylase TTLL4; Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS/MB21D1. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase- generates monoglutamylation of CGAS/MB21D1, leading to impair the nucleotidyltransferase activity of CGAS/MB21D1; Tubulin tyrosine ligase family | 0.571 |
FIGN | ZFYVE26 | ENSP00000333836 | ENSP00000251119 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis- recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair; Zinc fingers FYVE-type | 0.620 |
NOX3 | PHTF2 | ENSP00000159060 | ENSP00000403042 | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | Putative homeodomain transcription factor 2; May play a role in transcription regulation | 0.517 |
PHTF2 | CACNA2D1 | ENSP00000403042 | ENSP00000349320 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | Voltage-dependent calcium channel subunit alpha-2/delta-1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) | 0.491 |
PHTF2 | FAM114A1 | ENSP00000403042 | ENSP00000351740 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family | 0.473 |
PHTF2 | FIGN | ENSP00000403042 | ENSP00000333836 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | 0.558 |
PHTF2 | NOX3 | ENSP00000403042 | ENSP00000159060 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | 0.517 |
PHTF2 | SHPRH | ENSP00000403042 | ENSP00000356475 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to ’Lys-164’ of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through ’Lys-63’; Belongs to the SNF2/RAD54 helicase family | 0.575 |
PHTF2 | SMARCAD1 | ENSP00000403042 | ENSP00000351947 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | ATP-dependent helicase 1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage- probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 ’Lys-9’ trimethylation (H3K9me3) and restorati [...] | 0.482 |
PHTF2 | SRSF7 | ENSP00000403042 | ENSP00000325905 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | Serine/arginine-rich splicing factor 7; Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific | 0.498 |
PHTF2 | TTLL4 | ENSP00000403042 | ENSP00000375951 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | Tubulin polyglutamylase TTLL4; Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS/MB21D1. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase- generates monoglutamylation of CGAS/MB21D1, leading to impair the nucleotidyltransferase activity of CGAS/MB21D1; Tubulin tyrosine ligase family | 0.545 |
PHTF2 | ZFYVE26 | ENSP00000403042 | ENSP00000251119 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis- recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair; Zinc fingers FYVE-type | 0.608 |
PHTF2 | ZNF518B | ENSP00000403042 | ENSP00000317614 | Putative homeodomain transcription factor 2; May play a role in transcription regulation | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.492 |