| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C6orf25 | TREML1 | ENSP00000364964 | ENSP00000402855 | Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response; V-set domain containing | 0.649 |
| CD300LB | TREM1 | ENSP00000376397 | ENSP00000244709 | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2; V-set domain containing | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock; CD molecules | 0.652 |
| CD300LB | TREM2 | ENSP00000376397 | ENSP00000362205 | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2; V-set domain containing | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines; V-set domain containing | 0.480 |
| CD300LB | TREML1 | ENSP00000376397 | ENSP00000402855 | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2; V-set domain containing | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response; V-set domain containing | 0.615 |
| CD300LB | TREML2 | ENSP00000376397 | ENSP00000418767 | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2; V-set domain containing | Trem-like transcript 2 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation; V-set domain containing | 0.467 |
| CD300LB | TREML4 | ENSP00000376397 | ENSP00000342570 | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2; V-set domain containing | Trem-like transcript 4 protein; Positively regulates Toll-like receptor TLR7 signaling in macrophages; V-set domain containing | 0.515 |
| CD300LB | TYROBP | ENSP00000376397 | ENSP00000262629 | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2; V-set domain containing | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.995 |
| EPHX4 | TREML1 | ENSP00000359410 | ENSP00000402855 | Epoxide hydrolase 4; Abhydrolase domain containing | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response; V-set domain containing | 0.650 |
| FCER1A | TREML1 | ENSP00000357097 | ENSP00000402855 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines; Immunoglobulin like domain containing | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response; V-set domain containing | 0.628 |
| FCER1A | TYROBP | ENSP00000357097 | ENSP00000262629 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines; Immunoglobulin like domain containing | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.521 |
| SELP | TREML1 | ENSP00000263686 | ENSP00000402855 | P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1; Belongs to the selectin/LECAM family | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response; V-set domain containing | 0.693 |
| SELP | TYROBP | ENSP00000263686 | ENSP00000262629 | P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1; Belongs to the selectin/LECAM family | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.413 |
| TREM1 | CD300LB | ENSP00000244709 | ENSP00000376397 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock; CD molecules | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2; V-set domain containing | 0.652 |
| TREM1 | TREM2 | ENSP00000244709 | ENSP00000362205 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock; CD molecules | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines; V-set domain containing | 0.918 |
| TREM1 | TREML1 | ENSP00000244709 | ENSP00000402855 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock; CD molecules | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response; V-set domain containing | 0.805 |
| TREM1 | TREML2 | ENSP00000244709 | ENSP00000418767 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock; CD molecules | Trem-like transcript 2 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation; V-set domain containing | 0.901 |
| TREM1 | TREML4 | ENSP00000244709 | ENSP00000342570 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock; CD molecules | Trem-like transcript 4 protein; Positively regulates Toll-like receptor TLR7 signaling in macrophages; V-set domain containing | 0.646 |
| TREM1 | TYROBP | ENSP00000244709 | ENSP00000262629 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock; CD molecules | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.989 |
| TREM2 | CD300LB | ENSP00000362205 | ENSP00000376397 | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines; V-set domain containing | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2; V-set domain containing | 0.480 |
| TREM2 | TREM1 | ENSP00000362205 | ENSP00000244709 | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines; V-set domain containing | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock; CD molecules | 0.918 |
