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STRINGSTRING
MED1 MED1 SLC39A3 SLC39A3 NR2C2AP NR2C2AP SIN3B SIN3B CHERP CHERP SLC35E1 SLC35E1 CIB3 CIB3 DDX49 DDX49 SUGP1 SUGP1 SLC25A42 SLC25A42 RFXANK RFXANK
"NR2C2AP" - Nuclear receptor 2C2-associated protein in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
NR2C2APNuclear receptor 2C2-associated protein; May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes; Belongs to the NR2C2AP family (167 aa)    
Predicted Functional Partners:
MED1
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...] (1581 aa)
          
    0.900
SLC35E1
Solute carrier family 35 member E1; Putative transporter; Solute carriers (410 aa)
            
  0.719
DDX49
Probable ATP-dependent RNA helicase DDX49; DEAD-box helicase 49; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily (483 aa)
      
   
  0.692
SLC25A42
Mitochondrial coenzyme A transporter SLC25A42; Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3’,5’- diphosphate; Solute carriers (318 aa)
            
  0.670
CHERP
Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing (916 aa)
      
   
  0.641
RFXANK
DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1 (By similarity); Ankyrin repeat domain containing (260 aa)
      
   
  0.640
CIB3
Calcium and integrin binding family member 3; EF-hand domain containing (187 aa)
            
  0.607
SUGP1
SURP and G-patch domain-containing protein 1; Plays a role in pre-mRNA splicing; G-patch domain containing (645 aa)
      
   
  0.602
SIN3B
Paired amphipathic helix protein Sin3b; Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (1162 aa)
      
   
  0.567
SLC39A3
Zinc transporter ZIP3; Acts as a zinc-influx transporter; Solute carriers (314 aa)
            
  0.535
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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