| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLDN22 | VSIG1 | ENSP00000318113 | ENSP00000402219 | Claudin-22; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | 0.435 |
| CPD | VSIG1 | ENSP00000225719 | ENSP00000402219 | M14 carboxypeptidases | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | 0.426 |
| CTSE | VSIG1 | ENSP00000350911 | ENSP00000402219 | Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Cathepsins | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | 0.471 |
| KRT36 | VSIG1 | ENSP00000329165 | ENSP00000402219 | Keratin, type I cuticular Ha6; Keratins, type I | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | 0.495 |
| SCIMP | SOX30 | ENSP00000461269 | ENSP00000265007 | SLP adapter and CSK-interacting membrane protein; Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation | Transcription factor SOX-30; Transcriptional activator. Binds to the DNA sequence 5’- ACAAT-3’ and shows a preference for guanine residues surrounding this core motif; SRY-boxes | 0.404 |
| SCIMP | TOPAZ1 | ENSP00000461269 | ENSP00000310303 | SLP adapter and CSK-interacting membrane protein; Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation | Testis- and ovary-specific PAZ domain-containing protein 1; Testis and ovary specific PAZ domain containing 1 | 0.402 |
| SCIMP | VSIG1 | ENSP00000461269 | ENSP00000402219 | SLP adapter and CSK-interacting membrane protein; Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | 0.407 |
| SOX30 | SCIMP | ENSP00000265007 | ENSP00000461269 | Transcription factor SOX-30; Transcriptional activator. Binds to the DNA sequence 5’- ACAAT-3’ and shows a preference for guanine residues surrounding this core motif; SRY-boxes | SLP adapter and CSK-interacting membrane protein; Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation | 0.404 |
| SOX30 | TOPAZ1 | ENSP00000265007 | ENSP00000310303 | Transcription factor SOX-30; Transcriptional activator. Binds to the DNA sequence 5’- ACAAT-3’ and shows a preference for guanine residues surrounding this core motif; SRY-boxes | Testis- and ovary-specific PAZ domain-containing protein 1; Testis and ovary specific PAZ domain containing 1 | 0.436 |
| SOX30 | VSIG1 | ENSP00000265007 | ENSP00000402219 | Transcription factor SOX-30; Transcriptional activator. Binds to the DNA sequence 5’- ACAAT-3’ and shows a preference for guanine residues surrounding this core motif; SRY-boxes | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | 0.421 |
| SULT2B1 | VSIG1 | ENSP00000201586 | ENSP00000402219 | Sulfotransferase family cytosolic 2B member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal choleste [...] | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | 0.533 |
| TOPAZ1 | SCIMP | ENSP00000310303 | ENSP00000461269 | Testis- and ovary-specific PAZ domain-containing protein 1; Testis and ovary specific PAZ domain containing 1 | SLP adapter and CSK-interacting membrane protein; Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation | 0.402 |
| TOPAZ1 | SOX30 | ENSP00000310303 | ENSP00000265007 | Testis- and ovary-specific PAZ domain-containing protein 1; Testis and ovary specific PAZ domain containing 1 | Transcription factor SOX-30; Transcriptional activator. Binds to the DNA sequence 5’- ACAAT-3’ and shows a preference for guanine residues surrounding this core motif; SRY-boxes | 0.436 |
| TOPAZ1 | VSIG1 | ENSP00000310303 | ENSP00000402219 | Testis- and ovary-specific PAZ domain-containing protein 1; Testis and ovary specific PAZ domain containing 1 | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | 0.430 |
| VPS29 | VPS35 | ENSP00000480853 | ENSP00000299138 | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo [...] | Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] | 0.999 |
| VPS29 | VSIG1 | ENSP00000480853 | ENSP00000402219 | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo [...] | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | 0.556 |
| VPS35 | VPS29 | ENSP00000299138 | ENSP00000480853 | Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo [...] | 0.999 |
| VPS35 | VSIG1 | ENSP00000299138 | ENSP00000402219 | Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | 0.661 |
| VSIG1 | CLDN22 | ENSP00000402219 | ENSP00000318113 | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | Claudin-22; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | 0.435 |
| VSIG1 | CPD | ENSP00000402219 | ENSP00000225719 | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily | M14 carboxypeptidases | 0.426 |
