SAMD3 protein (human) - STRING database

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SAMD3

Sterile alpha motif domain containing 3 (544 aa)

Predicted Functional Partners:

ANKS3

0.667

ABLIM1

0.665

DNM3

0.659

ANKS6

0.638

SMAD3

0.605

SEMA3E

0.598

BICC1

0.570

SMAD2

0.528

NEK8

0.479

NEK9

0.453

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABLIM1	SAMD3	ENSP00000277895	ENSP00000402092	Actin-binding LIM protein 1; May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance; LIM domain containing	Sterile alpha motif domain containing 3	0.665
ANKS3	ANKS6	ENSP00000304586	ENSP00000297837	Ankyrin repeat and sterile alpha motif domain containing 3	Ankyrin repeat and SAM domain-containing protein 6; Required for renal function; Ankyrin repeat domain containing	0.501
ANKS3	NEK8	ENSP00000304586	ENSP00000268766	Ankyrin repeat and sterile alpha motif domain containing 3	Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway	0.852
ANKS3	NEK9	ENSP00000304586	ENSP00000238616	Ankyrin repeat and sterile alpha motif domain containing 3	Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively; Belongs to the protein kinase superfamily. NEK Ser/Thr protein k [...]	0.679
ANKS3	SAMD3	ENSP00000304586	ENSP00000402092	Ankyrin repeat and sterile alpha motif domain containing 3	Sterile alpha motif domain containing 3	0.667
ANKS6	ANKS3	ENSP00000297837	ENSP00000304586	Ankyrin repeat and SAM domain-containing protein 6; Required for renal function; Ankyrin repeat domain containing	Ankyrin repeat and sterile alpha motif domain containing 3	0.501
ANKS6	NEK8	ENSP00000297837	ENSP00000268766	Ankyrin repeat and SAM domain-containing protein 6; Required for renal function; Ankyrin repeat domain containing	Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway	0.864
ANKS6	NEK9	ENSP00000297837	ENSP00000238616	Ankyrin repeat and SAM domain-containing protein 6; Required for renal function; Ankyrin repeat domain containing	Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively; Belongs to the protein kinase superfamily. NEK Ser/Thr protein k [...]	0.829
ANKS6	SAMD3	ENSP00000297837	ENSP00000402092	Ankyrin repeat and SAM domain-containing protein 6; Required for renal function; Ankyrin repeat domain containing	Sterile alpha motif domain containing 3	0.638
BICC1	NEK8	ENSP00000362993	ENSP00000268766	Protein bicaudal C homolog 1; Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development; Sterile alpha motif domain containing	Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway	0.406
BICC1	SAMD3	ENSP00000362993	ENSP00000402092	Protein bicaudal C homolog 1; Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development; Sterile alpha motif domain containing	Sterile alpha motif domain containing 3	0.570
DNM3	SAMD3	ENSP00000356705	ENSP00000402092	Dynamin-3; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family	Sterile alpha motif domain containing 3	0.659
NEK8	ANKS3	ENSP00000268766	ENSP00000304586	Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway	Ankyrin repeat and sterile alpha motif domain containing 3	0.852
NEK8	ANKS6	ENSP00000268766	ENSP00000297837	Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway	Ankyrin repeat and SAM domain-containing protein 6; Required for renal function; Ankyrin repeat domain containing	0.864
NEK8	BICC1	ENSP00000268766	ENSP00000362993	Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway	Protein bicaudal C homolog 1; Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development; Sterile alpha motif domain containing	0.406
NEK8	NEK9	ENSP00000268766	ENSP00000238616	Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway	Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively; Belongs to the protein kinase superfamily. NEK Ser/Thr protein k [...]	0.428
NEK8	SAMD3	ENSP00000268766	ENSP00000402092	Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway	Sterile alpha motif domain containing 3	0.479
NEK9	ANKS3	ENSP00000238616	ENSP00000304586	Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively; Belongs to the protein kinase superfamily. NEK Ser/Thr protein k [...]	Ankyrin repeat and sterile alpha motif domain containing 3	0.679
NEK9	ANKS6	ENSP00000238616	ENSP00000297837	Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively; Belongs to the protein kinase superfamily. NEK Ser/Thr protein k [...]	Ankyrin repeat and SAM domain-containing protein 6; Required for renal function; Ankyrin repeat domain containing	0.829
NEK9	NEK8	ENSP00000238616	ENSP00000268766	Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively; Belongs to the protein kinase superfamily. NEK Ser/Thr protein k [...]	Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway	0.428

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