node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CST3 | PDZD2 | ENSP00000381448 | ENSP00000402033 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | PDZ domain containing 2 | 0.585 |
CTNND2 | ERBB2IP | ENSP00000307134 | ENSP00000426632 | Catenin delta-2; Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta- catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules | Erbin; Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ’Tyr-1248’ of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion; Belongs to the LAP (LRR and PDZ) protein family | 0.671 |
CTNND2 | PDZD2 | ENSP00000307134 | ENSP00000402033 | Catenin delta-2; Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta- catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules | PDZ domain containing 2 | 0.824 |
DLGAP2 | PDZD2 | ENSP00000400258 | ENSP00000402033 | Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane; Belongs to the SAPAP family | PDZ domain containing 2 | 0.512 |
ERBB2IP | CTNND2 | ENSP00000426632 | ENSP00000307134 | Erbin; Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ’Tyr-1248’ of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion; Belongs to the LAP (LRR and PDZ) protein family | Catenin delta-2; Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta- catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules | 0.671 |
ERBB2IP | PDZD2 | ENSP00000426632 | ENSP00000402033 | Erbin; Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ’Tyr-1248’ of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion; Belongs to the LAP (LRR and PDZ) protein family | PDZ domain containing 2 | 0.689 |
ERBB2IP | PKP4 | ENSP00000426632 | ENSP00000374409 | Erbin; Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ’Tyr-1248’ of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion; Belongs to the LAP (LRR and PDZ) protein family | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques; Armadillo repeat containing | 0.879 |
ERBB2IP | PRKCI | ENSP00000426632 | ENSP00000295797 | Erbin; Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ’Tyr-1248’ of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion; Belongs to the LAP (LRR and PDZ) protein family | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process a [...] | 0.445 |
PDZD2 | CST3 | ENSP00000402033 | ENSP00000381448 | PDZ domain containing 2 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family | 0.585 |
PDZD2 | CTNND2 | ENSP00000402033 | ENSP00000307134 | PDZ domain containing 2 | Catenin delta-2; Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta- catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules | 0.824 |
PDZD2 | DLGAP2 | ENSP00000402033 | ENSP00000400258 | PDZ domain containing 2 | Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane; Belongs to the SAPAP family | 0.512 |
PDZD2 | ERBB2IP | ENSP00000402033 | ENSP00000426632 | PDZ domain containing 2 | Erbin; Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ’Tyr-1248’ of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion; Belongs to the LAP (LRR and PDZ) protein family | 0.689 |
PDZD2 | PDZD3 | ENSP00000402033 | ENSP00000347742 | PDZ domain containing 2 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions; PDZ domain containing | 0.560 |
PDZD2 | PKP4 | ENSP00000402033 | ENSP00000374409 | PDZ domain containing 2 | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques; Armadillo repeat containing | 0.844 |
PDZD2 | PRDM5 | ENSP00000402033 | ENSP00000264808 | PDZ domain containing 2 | PR domain zinc finger protein 5; Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. Ma [...] | 0.518 |
PDZD2 | PRKCI | ENSP00000402033 | ENSP00000295797 | PDZ domain containing 2 | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process a [...] | 0.513 |
PDZD2 | PRKCZ | ENSP00000402033 | ENSP00000367830 | PDZ domain containing 2 | Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Requ [...] | 0.523 |
PDZD2 | PROM2 | ENSP00000402033 | ENSP00000318270 | PDZ domain containing 2 | Prominin-2; Prominin 2 | 0.576 |
PDZD3 | PDZD2 | ENSP00000347742 | ENSP00000402033 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions; PDZ domain containing | PDZ domain containing 2 | 0.560 |
PKP4 | ERBB2IP | ENSP00000374409 | ENSP00000426632 | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques; Armadillo repeat containing | Erbin; Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ’Tyr-1248’ of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion; Belongs to the LAP (LRR and PDZ) protein family | 0.879 |