ZNF223 protein (human) - STRING database

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ZNF223

Zinc finger protein 223; May be involved in transcriptional regulation; Zinc fingers C2H2-type (482 aa)

Predicted Functional Partners:

TRIM28

0.913

HAUS2

0.779

EVI5

0.778

USP49

0.772

HSD17B7

0.556

ALPP

0.555

ANKRD44

0.554

NUBPL

0.533

ASCC2

0.473

MOK

0.443

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPP	HSD17B7	ENSP00000375881	ENSP00000254521	Alkaline phosphatase, placental	3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily	0.559
ALPP	USP49	ENSP00000375881	ENSP00000377797	Alkaline phosphatase, placental	Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at ’Lys-120’ (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family	0.673
ALPP	ZNF223	ENSP00000375881	ENSP00000401947	Alkaline phosphatase, placental	Zinc finger protein 223; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.555
ANKRD44	ASCC2	ENSP00000282272	ENSP00000380877	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates; Ankyrin repeat domain containing	Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	0.474
ANKRD44	ZNF223	ENSP00000282272	ENSP00000401947	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates; Ankyrin repeat domain containing	Zinc finger protein 223; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.554
ASCC2	ANKRD44	ENSP00000380877	ENSP00000282272	Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates; Ankyrin repeat domain containing	0.474
ASCC2	ZNF223	ENSP00000380877	ENSP00000401947	Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation	Zinc finger protein 223; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.473
EVI5	HAUS2	ENSP00000359356	ENSP00000260372	Ecotropic viral integration site 5 protein homolog; Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis	HAUS augmin-like complex subunit 2; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex	0.684
EVI5	ZNF223	ENSP00000359356	ENSP00000401947	Ecotropic viral integration site 5 protein homolog; Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis	Zinc finger protein 223; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.778
HAUS2	EVI5	ENSP00000260372	ENSP00000359356	HAUS augmin-like complex subunit 2; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex	Ecotropic viral integration site 5 protein homolog; Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis	0.684
HAUS2	HSD17B7	ENSP00000260372	ENSP00000254521	HAUS augmin-like complex subunit 2; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex	3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily	0.650
HAUS2	NUBPL	ENSP00000260372	ENSP00000281081	HAUS augmin-like complex subunit 2; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex	Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits; Belongs to the Mrp/NBP35 ATP-binding proteins family	0.546
HAUS2	USP49	ENSP00000260372	ENSP00000377797	HAUS augmin-like complex subunit 2; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex	Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at ’Lys-120’ (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family	0.674
HAUS2	ZNF223	ENSP00000260372	ENSP00000401947	HAUS augmin-like complex subunit 2; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex	Zinc finger protein 223; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.779
HSD17B7	ALPP	ENSP00000254521	ENSP00000375881	3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily	Alkaline phosphatase, placental	0.559
HSD17B7	HAUS2	ENSP00000254521	ENSP00000260372	3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily	HAUS augmin-like complex subunit 2; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex	0.650
HSD17B7	USP49	ENSP00000254521	ENSP00000377797	3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily	Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at ’Lys-120’ (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family	0.560
HSD17B7	ZNF223	ENSP00000254521	ENSP00000401947	3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily	Zinc finger protein 223; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.556
MOK	ZNF223	ENSP00000355304	ENSP00000401947	MAPK/MAK/MRK overlapping kinase; Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily	Zinc finger protein 223; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.443
NUBPL	HAUS2	ENSP00000281081	ENSP00000260372	Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits; Belongs to the Mrp/NBP35 ATP-binding proteins family	HAUS augmin-like complex subunit 2; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex	0.546

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