| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATR | CHEK2 | ENSP00000343741 | ENSP00000372023 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage r [...] | Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...] | 0.999 |
| ATR | RFX5 | ENSP00000343741 | ENSP00000290524 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage r [...] | DNA-binding protein RFX5; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters; Belongs to the RFX family | 0.427 |
| ATR | RFX7 | ENSP00000343741 | ENSP00000453281 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage r [...] | DNA-binding protein RFX7; Regulatory factor X family; Belongs to the RFX family | 0.427 |
| ATR | RFX8 | ENSP00000343741 | ENSP00000401536 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage r [...] | DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family | 0.427 |
| CHEK2 | ATR | ENSP00000372023 | ENSP00000343741 | Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...] | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage r [...] | 0.999 |
| CHEK2 | RFX5 | ENSP00000372023 | ENSP00000290524 | Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...] | DNA-binding protein RFX5; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters; Belongs to the RFX family | 0.435 |
| CHEK2 | RFX7 | ENSP00000372023 | ENSP00000453281 | Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...] | DNA-binding protein RFX7; Regulatory factor X family; Belongs to the RFX family | 0.441 |
| CHEK2 | RFX8 | ENSP00000372023 | ENSP00000401536 | Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...] | DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family | 0.435 |
| FAM174B | FAM228A | ENSP00000329040 | ENSP00000295150 | Membrane protein FAM174B; Family with sequence similarity 174 member B | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | 0.583 |
| FAM174B | RFX8 | ENSP00000329040 | ENSP00000401536 | Membrane protein FAM174B; Family with sequence similarity 174 member B | DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family | 0.470 |
| FAM174B | SPATA17 | ENSP00000329040 | ENSP00000355900 | Membrane protein FAM174B; Family with sequence similarity 174 member B | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | 0.420 |
| FAM174B | TMEM71 | ENSP00000329040 | ENSP00000349296 | Membrane protein FAM174B; Family with sequence similarity 174 member B | Transmembrane protein 71; Belongs to the TMEM71 family | 0.470 |
| FAM228A | FAM174B | ENSP00000295150 | ENSP00000329040 | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | Membrane protein FAM174B; Family with sequence similarity 174 member B | 0.583 |
| FAM228A | RFX8 | ENSP00000295150 | ENSP00000401536 | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family | 0.646 |
| FAM228A | SPATA17 | ENSP00000295150 | ENSP00000355900 | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 | 0.585 |
| FAM228A | TMEM71 | ENSP00000295150 | ENSP00000349296 | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | Transmembrane protein 71; Belongs to the TMEM71 family | 0.645 |
| GTF2IRD2B | RFX8 | ENSP00000480524 | ENSP00000401536 | General transcription factor II-I repeat domain-containing protein 2B; GTF2I repeat domain containing 2B; Belongs to the TFII-I family | DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family | 0.420 |
| GTF2IRD2B | RPSAP58 | ENSP00000480524 | ENSP00000417240 | General transcription factor II-I repeat domain-containing protein 2B; GTF2I repeat domain containing 2B; Belongs to the TFII-I family | Ribosomal protein SA pseudogene 58 | 0.473 |
| RFX5 | ATR | ENSP00000290524 | ENSP00000343741 | DNA-binding protein RFX5; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters; Belongs to the RFX family | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates ’Ser-139’ of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage r [...] | 0.427 |
| RFX5 | CHEK2 | ENSP00000290524 | ENSP00000372023 | DNA-binding protein RFX5; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters; Belongs to the RFX family | Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...] | 0.435 |
