node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGB2 | HTRA4 | ENSP00000352295 | ENSP00000305919 | Chorionic gonadotropin beta subunit 2 | Serine protease HTRA4; Serine protease; PDZ domain containing | 0.448 |
CGB2 | SIGLEC6 | ENSP00000352295 | ENSP00000401502 | Chorionic gonadotropin beta subunit 2 | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | 0.400 |
FCRL4 | SIGLEC6 | ENSP00000271532 | ENSP00000401502 | Fc receptor-like protein 4; May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response; CD molecules | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | 0.502 |
HTRA4 | CGB2 | ENSP00000305919 | ENSP00000352295 | Serine protease HTRA4; Serine protease; PDZ domain containing | Chorionic gonadotropin beta subunit 2 | 0.448 |
HTRA4 | PAPPA2 | ENSP00000305919 | ENSP00000356634 | Serine protease HTRA4; Serine protease; PDZ domain containing | Pappalysin-2; Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the ’163-Ser-|- Lys-164’ bond. Shows limited proteolysis toward IGFBP-3; Belongs to the peptidase M43B family | 0.555 |
HTRA4 | SIGLEC6 | ENSP00000305919 | ENSP00000401502 | Serine protease HTRA4; Serine protease; PDZ domain containing | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | 0.441 |
INHA | PAPPA2 | ENSP00000243786 | ENSP00000356634 | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family | Pappalysin-2; Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the ’163-Ser-|- Lys-164’ bond. Shows limited proteolysis toward IGFBP-3; Belongs to the peptidase M43B family | 0.493 |
INHA | SIGLEC6 | ENSP00000243786 | ENSP00000401502 | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | 0.414 |
LEP | SIGLEC6 | ENSP00000312652 | ENSP00000401502 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal met [...] | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | 0.603 |
PAEP | SIGLEC6 | ENSP00000417898 | ENSP00000401502 | Glycodelin; Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa- zona pellucida binding and significantly suppresses progesterone- induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the [...] | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | 0.531 |
PAPPA2 | HTRA4 | ENSP00000356634 | ENSP00000305919 | Pappalysin-2; Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the ’163-Ser-|- Lys-164’ bond. Shows limited proteolysis toward IGFBP-3; Belongs to the peptidase M43B family | Serine protease HTRA4; Serine protease; PDZ domain containing | 0.555 |
PAPPA2 | INHA | ENSP00000356634 | ENSP00000243786 | Pappalysin-2; Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the ’163-Ser-|- Lys-164’ bond. Shows limited proteolysis toward IGFBP-3; Belongs to the peptidase M43B family | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family | 0.493 |
PAPPA2 | SIGLEC6 | ENSP00000356634 | ENSP00000401502 | Pappalysin-2; Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the ’163-Ser-|- Lys-164’ bond. Shows limited proteolysis toward IGFBP-3; Belongs to the peptidase M43B family | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | 0.632 |
SIGLEC6 | CGB2 | ENSP00000401502 | ENSP00000352295 | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | Chorionic gonadotropin beta subunit 2 | 0.400 |
SIGLEC6 | FCRL4 | ENSP00000401502 | ENSP00000271532 | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | Fc receptor-like protein 4; May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response; CD molecules | 0.502 |
SIGLEC6 | HTRA4 | ENSP00000401502 | ENSP00000305919 | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | Serine protease HTRA4; Serine protease; PDZ domain containing | 0.441 |
SIGLEC6 | INHA | ENSP00000401502 | ENSP00000243786 | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family | 0.414 |
SIGLEC6 | LEP | ENSP00000401502 | ENSP00000312652 | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal met [...] | 0.603 |
SIGLEC6 | PAEP | ENSP00000401502 | ENSP00000417898 | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | Glycodelin; Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa- zona pellucida binding and significantly suppresses progesterone- induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the [...] | 0.531 |
SIGLEC6 | PAPPA2 | ENSP00000401502 | ENSP00000356634 | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface; Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family | Pappalysin-2; Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the ’163-Ser-|- Lys-164’ bond. Shows limited proteolysis toward IGFBP-3; Belongs to the peptidase M43B family | 0.632 |