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  • 11.0 [archived version]
STRINGSTRING
OTOA OTOA CEACAM16 CEACAM16 TECTB TECTB OTOL1 OTOL1 STRC STRC OTOGL OTOGL MCUR1 MCUR1 TMEM236 TMEM236 MYLK4 MYLK4 TMEM191B TMEM191B OR13C8 OR13C8
"OTOGL" - Otogelin-like protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OTOGLOtogelin-like protein; Otogelin like (2344 aa)    
Predicted Functional Partners:
MYLK4
Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family (388 aa)
            
  0.711
OTOA
Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family (1139 aa)
            
  0.684
CEACAM16
Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane; Belongs to the immunoglobulin superfamily. CEA family (425 aa)
            
  0.676
OTOL1
Otolin-1; C1q and TNF related ; Belongs to the OTOL1 family (477 aa)
      
   
  0.669
MCUR1
Mitochondrial calcium uniporter regulator 1; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex); Belongs to the CCDC90 family (359 aa)
            
  0.666
TECTB
Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals (329 aa)
      
   
  0.656
STRC
Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia; Belongs to the stereocilin family (1775 aa)
            
  0.625
TMEM191B
Transmembrane protein 191B (346 aa)
            
  0.609
TMEM236
Transmembrane protein 236 (351 aa)
            
  0.609
OR13C8
Olfactory receptor 13C8; Odorant receptor; Olfactory receptors, family 13 (320 aa)
            
  0.589
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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