| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKIP1 | LRRC69 | ENSP00000310459 | ENSP00000400803 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | 0.534 |
| C6orf25 | FAM198B | ENSP00000364964 | ENSP00000377396 | Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner | Protein FAM198B; Family with sequence similarity 198 member B; Belongs to the FAM198 family | 0.432 |
| C6orf25 | LRRC46 | ENSP00000364964 | ENSP00000269025 | Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.515 |
| C6orf25 | LRRC69 | ENSP00000364964 | ENSP00000400803 | Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | 0.573 |
| FAM198B | C6orf25 | ENSP00000377396 | ENSP00000364964 | Protein FAM198B; Family with sequence similarity 198 member B; Belongs to the FAM198 family | Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner | 0.432 |
| FAM198B | LRRC46 | ENSP00000377396 | ENSP00000269025 | Protein FAM198B; Family with sequence similarity 198 member B; Belongs to the FAM198 family | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.549 |
| FAM198B | LRRC69 | ENSP00000377396 | ENSP00000400803 | Protein FAM198B; Family with sequence similarity 198 member B; Belongs to the FAM198 family | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | 0.575 |
| FAM198B | TEX15 | ENSP00000377396 | ENSP00000256246 | Protein FAM198B; Family with sequence similarity 198 member B; Belongs to the FAM198 family | Testis-expressed protein 15; Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair | 0.424 |
| LPHN1 | LRRC46 | ENSP00000340688 | ENSP00000269025 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.683 |
| LPHN1 | LRRC6 | ENSP00000340688 | ENSP00000484634 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility | 0.683 |
| LPHN1 | LRRC69 | ENSP00000340688 | ENSP00000400803 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | 0.685 |
| LPHN2 | LRRC46 | ENSP00000322270 | ENSP00000269025 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.683 |
| LPHN2 | LRRC6 | ENSP00000322270 | ENSP00000484634 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility | 0.683 |
| LPHN2 | LRRC69 | ENSP00000322270 | ENSP00000400803 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | 0.685 |
| LPHN3 | LRRC46 | ENSP00000422533 | ENSP00000269025 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | 0.683 |
| LPHN3 | LRRC6 | ENSP00000422533 | ENSP00000484634 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility | 0.683 |
| LPHN3 | LRRC69 | ENSP00000422533 | ENSP00000400803 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 | 0.685 |
| LRRC46 | C6orf25 | ENSP00000269025 | ENSP00000364964 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner | 0.515 |
| LRRC46 | FAM198B | ENSP00000269025 | ENSP00000377396 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Protein FAM198B; Family with sequence similarity 198 member B; Belongs to the FAM198 family | 0.549 |
| LRRC46 | LPHN1 | ENSP00000269025 | ENSP00000340688 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.683 |
