C1orf159 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

C1orf159

Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159 (198 aa)

Predicted Functional Partners:

OR10J3

0.530

COMMD4

0.499

PLEKHS1

0.474

UXS1

0.446

DENND4A

0.445

TMEM57

0.442

GSPT2

0.424

CCDC103

0.422

PPP1R14C

0.400

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf159	CCDC103	ENSP00000400736	ENSP00000391692	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	0.422
C1orf159	COMMD4	ENSP00000400736	ENSP00000267935	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	COMM domain-containing protein 4; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B	0.499
C1orf159	DENND4A	ENSP00000400736	ENSP00000391167	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	C-myc promoter-binding protein; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed-8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter; DENN/MADD domain containing	0.445
C1orf159	GSPT2	ENSP00000400736	ENSP00000341247	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons	0.424
C1orf159	OR10J3	ENSP00000400736	ENSP00000331789	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	Olfactory receptor 10J3; Odorant receptor; Olfactory receptors, family 10	0.530
C1orf159	PLEKHS1	ENSP00000400736	ENSP00000358316	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	Pleckstrin homology domain containing S1	0.474
C1orf159	PPP1R14C	ENSP00000400736	ENSP00000355260	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA	0.400
C1orf159	TMEM57	ENSP00000400736	ENSP00000363463	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	Macoilin; Transmembrane protein 57	0.442
C1orf159	UXS1	ENSP00000400736	ENSP00000283148	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis; Short chain dehydrogenase/reductase superfamily	0.446
CCDC103	C1orf159	ENSP00000391692	ENSP00000400736	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	0.422
CCDC103	OR10J3	ENSP00000391692	ENSP00000331789	Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family	Olfactory receptor 10J3; Odorant receptor; Olfactory receptors, family 10	0.400
COMMD4	C1orf159	ENSP00000267935	ENSP00000400736	COMM domain-containing protein 4; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	0.499
COMMD4	DENND4A	ENSP00000267935	ENSP00000391167	COMM domain-containing protein 4; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B	C-myc promoter-binding protein; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed-8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter; DENN/MADD domain containing	0.410
COMMD4	OR10J3	ENSP00000267935	ENSP00000331789	COMM domain-containing protein 4; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B	Olfactory receptor 10J3; Odorant receptor; Olfactory receptors, family 10	0.473
COMMD4	TMEM57	ENSP00000267935	ENSP00000363463	COMM domain-containing protein 4; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B	Macoilin; Transmembrane protein 57	0.416
DENND4A	C1orf159	ENSP00000391167	ENSP00000400736	C-myc promoter-binding protein; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed-8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter; DENN/MADD domain containing	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	0.445
DENND4A	COMMD4	ENSP00000391167	ENSP00000267935	C-myc promoter-binding protein; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed-8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter; DENN/MADD domain containing	COMM domain-containing protein 4; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B	0.410
DENND4A	OR10J3	ENSP00000391167	ENSP00000331789	C-myc promoter-binding protein; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed-8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter; DENN/MADD domain containing	Olfactory receptor 10J3; Odorant receptor; Olfactory receptors, family 10	0.424
GSPT2	C1orf159	ENSP00000341247	ENSP00000400736	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	0.424
OR10J3	C1orf159	ENSP00000331789	ENSP00000400736	Olfactory receptor 10J3; Odorant receptor; Olfactory receptors, family 10	Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159	0.530

page 1 of 2

Network

Cooccurrence

Textmining

Coexpression

Experiments

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About