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  • 11.0 [archived version]
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KIAA0430 KIAA0430 TACO1 TACO1 CHCHD1 CHCHD1 MTIF3 MTIF3 FASTKD1 FASTKD1 PTCD3 PTCD3 RPUSD3 RPUSD3 PTCD2 PTCD2 GRSF1 GRSF1 FASTK FASTK RPUSD4 RPUSD4
"FASTKD1" - FAST kinase domain-containing protein 1, mitochondrial in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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FASTKD1FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family (847 aa)    
Predicted Functional Partners:
FASTK
Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor; Belongs to the FAST protein kinase family (549 aa)
           
  0.772
CHCHD1
Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins (118 aa)
           
  0.634
RPUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3; Major enzyme responsible for the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT- CO1) mRNA and at position 697-699 in mitochondrial COXIII (MT-CO3) mRNA, modulating the efficiency of mitochondrial protein synthesis without changes in transcript abundance or stability; Belongs to the pseudouridine synthase RluA family (351 aa)
           
  0.605
RPUSD4
Mitochondrial RNA pseudouridine synthase RPUSD4; Converts specific uridines to pseudouridine (PSI) in different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe); Belongs to the pseudouridine synthase RluA family (377 aa)
           
  0.575
KIAA0430
Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity) (1742 aa)
           
  0.534
PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial; Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function (388 aa)
     
   
  0.529
GRSF1
G-rich sequence factor 1; Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (480 aa)
     
   
  0.518
TACO1
Translational activator of cytochrome c oxidase 1; Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1; Belongs to the TACO1 family (297 aa)
           
  0.517
MTIF3
Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins (278 aa)
           
  0.512
PTCD3
Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation (689 aa)
     
   
  0.510
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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