node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHCHD1 | FASTKD1 | ENSP00000361923 | ENSP00000400513 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | 0.634 |
CHCHD1 | MTIF3 | ENSP00000361923 | ENSP00000370508 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins | 0.953 |
CHCHD1 | PTCD3 | ENSP00000361923 | ENSP00000254630 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation | 0.994 |
CHCHD1 | TACO1 | ENSP00000361923 | ENSP00000258975 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | Translational activator of cytochrome c oxidase 1; Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1; Belongs to the TACO1 family | 0.533 |
FASTK | FASTKD1 | ENSP00000297532 | ENSP00000400513 | Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor; Belongs to the FAST protein kinase family | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | 0.772 |
FASTK | GRSF1 | ENSP00000297532 | ENSP00000254799 | Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor; Belongs to the FAST protein kinase family | G-rich sequence factor 1; Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences | 0.601 |
FASTK | PTCD2 | ENSP00000297532 | ENSP00000370013 | Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor; Belongs to the FAST protein kinase family | Pentatricopeptide repeat-containing protein 2, mitochondrial; Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function | 0.474 |
FASTK | RPUSD3 | ENSP00000297532 | ENSP00000373331 | Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor; Belongs to the FAST protein kinase family | Mitochondrial mRNA pseudouridine synthase RPUSD3; Major enzyme responsible for the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT- CO1) mRNA and at position 697-699 in mitochondrial COXIII (MT-CO3) mRNA, modulating the efficiency of mitochondrial protein synthesis without changes in transcript abundance or stability; Belongs to the pseudouridine synthase RluA family | 0.520 |
FASTK | RPUSD4 | ENSP00000297532 | ENSP00000298317 | Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor; Belongs to the FAST protein kinase family | Mitochondrial RNA pseudouridine synthase RPUSD4; Converts specific uridines to pseudouridine (PSI) in different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe); Belongs to the pseudouridine synthase RluA family | 0.497 |
FASTKD1 | CHCHD1 | ENSP00000400513 | ENSP00000361923 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | 0.634 |
FASTKD1 | FASTK | ENSP00000400513 | ENSP00000297532 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor; Belongs to the FAST protein kinase family | 0.772 |
FASTKD1 | GRSF1 | ENSP00000400513 | ENSP00000254799 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | G-rich sequence factor 1; Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences | 0.518 |
FASTKD1 | KIAA0430 | ENSP00000400513 | ENSP00000379654 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity) | 0.534 |
FASTKD1 | MTIF3 | ENSP00000400513 | ENSP00000370508 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins | 0.512 |
FASTKD1 | PTCD2 | ENSP00000400513 | ENSP00000370013 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | Pentatricopeptide repeat-containing protein 2, mitochondrial; Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function | 0.529 |
FASTKD1 | PTCD3 | ENSP00000400513 | ENSP00000254630 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation | 0.510 |
FASTKD1 | RPUSD3 | ENSP00000400513 | ENSP00000373331 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | Mitochondrial mRNA pseudouridine synthase RPUSD3; Major enzyme responsible for the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT- CO1) mRNA and at position 697-699 in mitochondrial COXIII (MT-CO3) mRNA, modulating the efficiency of mitochondrial protein synthesis without changes in transcript abundance or stability; Belongs to the pseudouridine synthase RluA family | 0.605 |
FASTKD1 | RPUSD4 | ENSP00000400513 | ENSP00000298317 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | Mitochondrial RNA pseudouridine synthase RPUSD4; Converts specific uridines to pseudouridine (PSI) in different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe); Belongs to the pseudouridine synthase RluA family | 0.575 |
FASTKD1 | TACO1 | ENSP00000400513 | ENSP00000258975 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family | Translational activator of cytochrome c oxidase 1; Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1; Belongs to the TACO1 family | 0.517 |
GRSF1 | FASTK | ENSP00000254799 | ENSP00000297532 | G-rich sequence factor 1; Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences | Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor; Belongs to the FAST protein kinase family | 0.601 |