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  • 11.0 [archived version]
STRINGSTRING
VEZT VEZT SYNCRIP SYNCRIP SLC25A11 SLC25A11 CMTM3 CMTM3 CMTM2 CMTM2 CKLF CKLF CMTM8 CMTM8 BLNK BLNK CMTM7 CMTM7 CMTM4 CMTM4 CMTM1 CMTM1
"CMTM3" - CKLF like MARVEL transmembrane domain containing 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CMTM3CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family (182 aa)    
Predicted Functional Partners:
CKLF
Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10 (152 aa)
     
   
  0.910
CMTM1
CKLF like MARVEL transmembrane domain containing 1 (286 aa)
           
  0.905
CMTM4
CKLF like MARVEL transmembrane domain containing 4 (234 aa)
           
  0.905
CMTM2
CKLF like MARVEL transmembrane domain containing 2; Belongs to the chemokine-like factor family (248 aa)
           
  0.905
BLNK
B-cell linker protein; Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- media [...] (456 aa)
       
 
  0.853
CMTM8
CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family (173 aa)
           
  0.743
CMTM7
CKLF like MARVEL transmembrane domain containing 7; Belongs to the chemokine-like factor family (175 aa)
     
   
  0.739
VEZT
Vezatin; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site; Belongs to the vezatin family (779 aa)
       
      0.708
SLC25A11
Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis (By similarity); Solute carriers (314 aa)
           
  0.666
SYNCRIP
Heterogeneous nuclear ribonucleoprotein Q; Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD- mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 [...] (623 aa)
     
   
  0.660
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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