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  • 11.0 [archived version]
STRINGSTRING
NEK3 NEK3 C9orf139 C9orf139 DYDC2 DYDC2 HIPK4 HIPK4 TERF2IP TERF2IP ZNF146 ZNF146 KLHL8 KLHL8 FAM114A2 FAM114A2 GPR22 GPR22 PITPNA PITPNA MFSD6 MFSD6
"ZNF146" - Zinc finger protein 146 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF146Zinc finger protein 146; Belongs to the krueppel C2H2-type zinc-finger protein family (292 aa)    
Predicted Functional Partners:
HIPK4
Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) (616 aa)
     
 
  0.649
FAM114A2
Protein FAM114A2; Family with sequence similarity 114 member A2; Belongs to the FAM114 family (505 aa)
           
  0.558
DYDC2
DPY30 domain containing 2; Belongs to the dpy-30 family (191 aa)
           
  0.534
KLHL8
Kelch-like protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN; BTB domain containing (620 aa)
       
 
  0.523
C9orf139
Uncharacterized protein C9orf139; Chromosome 9 open reading frame 139 (190 aa)
           
  0.514
MFSD6
Major facilitator superfamily domain containing 6 (791 aa)
           
  0.511
TERF2IP
Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HD [...] (399 aa)
       
 
  0.510
GPR22
Probable G-protein coupled receptor 22; Orphan receptor; G protein-coupled receptors, Class A orphans (433 aa)
       
 
  0.455
NEK3
Serine/threonine-protein kinase Nek3; Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin- mediated phosphorylation of PXN and VAV2. Implicated in prolactin- mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily (506 aa)
       
 
  0.454
PITPNA
Phosphatidylinositol transfer protein alpha isoform; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes; Phosphatidylinositol transfer proteins (270 aa)
     
 
  0.448
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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