ZNF839 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ZNF839

Zinc finger protein 839 (927 aa)

Predicted Functional Partners:

TRIM28

0.900

C14orf79

0.795

ZFYVE21

0.669

WDR20

0.558

BAG5

0.514

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG5	C14orf79	ENSP00000338814	ENSP00000450114	BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family	Uncharacterized protein CLBA1; Chromosome 14 open reading frame 79	0.473
BAG5	ZNF839	ENSP00000338814	ENSP00000399863	BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family	Zinc finger protein 839	0.514
C14orf79	BAG5	ENSP00000450114	ENSP00000338814	Uncharacterized protein CLBA1; Chromosome 14 open reading frame 79	BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family	0.473
C14orf79	WDR20	ENSP00000450114	ENSP00000406084	Uncharacterized protein CLBA1; Chromosome 14 open reading frame 79	WD repeat-containing protein 20; Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme; WD repeat domain containing	0.526
C14orf79	ZFYVE21	ENSP00000450114	ENSP00000216602	Uncharacterized protein CLBA1; Chromosome 14 open reading frame 79	Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression; Zinc fingers FYVE-type	0.645
C14orf79	ZNF839	ENSP00000450114	ENSP00000399863	Uncharacterized protein CLBA1; Chromosome 14 open reading frame 79	Zinc finger protein 839	0.795
TRIM28	ZNF839	ENSP00000253024	ENSP00000399863	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Zinc finger protein 839	0.900
WDR20	C14orf79	ENSP00000406084	ENSP00000450114	WD repeat-containing protein 20; Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme; WD repeat domain containing	Uncharacterized protein CLBA1; Chromosome 14 open reading frame 79	0.526
WDR20	ZNF839	ENSP00000406084	ENSP00000399863	WD repeat-containing protein 20; Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme; WD repeat domain containing	Zinc finger protein 839	0.558
ZFYVE21	C14orf79	ENSP00000216602	ENSP00000450114	Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression; Zinc fingers FYVE-type	Uncharacterized protein CLBA1; Chromosome 14 open reading frame 79	0.645
ZFYVE21	ZNF839	ENSP00000216602	ENSP00000399863	Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression; Zinc fingers FYVE-type	Zinc finger protein 839	0.669
ZNF839	BAG5	ENSP00000399863	ENSP00000338814	Zinc finger protein 839	BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family	0.514
ZNF839	C14orf79	ENSP00000399863	ENSP00000450114	Zinc finger protein 839	Uncharacterized protein CLBA1; Chromosome 14 open reading frame 79	0.795
ZNF839	TRIM28	ENSP00000399863	ENSP00000253024	Zinc finger protein 839	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	0.900
ZNF839	WDR20	ENSP00000399863	ENSP00000406084	Zinc finger protein 839	WD repeat-containing protein 20; Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme; WD repeat domain containing	0.558
ZNF839	ZFYVE21	ENSP00000399863	ENSP00000216602	Zinc finger protein 839	Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression; Zinc fingers FYVE-type	0.669

Network

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

Experiments

Fusion

© STRING Consortium 2020

Credits

Access

Info

About